{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(10)"],"submitter":["Jia H"],"pubmed_abstract":["<h4>Introduction</h4>There is a lack of evidence on the efficacy of extracorporeal blood purification (EBP) to reduce the mortality rate in septic shock. We have designed the EABPSS (Efficacy of Adaptive Blood Purification for Septic Shock) study to confirm whether adaptive blood purification (ABP) intervention could confer a clinical benefit.<h4>Methods and analysis</h4>In this multicentre, open-label, randomised controlled trial, we are recruiting a total of 276 patients with septic shock. Eligible patients who provide informed consent will be randomly assigned in a 1:1 ratio to either the control group or the intervention group. Patients in the control group will receive standard care according to the Surviving Sepsis Guidelines. Patients in the intervention group will receive two 6-hou"],"journal":["BMJ open"],"pagination":["e107311"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12542525"],"repository":["biostudies-literature"],"pubmed_title":["Efficacy of Adaptive Blood Purification for Septic Shock (EABPSS): protocol for a randomised, multicentre, parallel controlled study."],"pmcid":["PMC12542525"],"pubmed_authors":["Li W","Li X","Zheng Y","Cui N","Ronco C","Jia H"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy of Adaptive Blood Purification for Septic Shock (EABPSS): protocol for a randomised, multicentre, parallel controlled study.","description":"<h4>Introduction</h4>There is a lack of evidence on the efficacy of extracorporeal blood purification (EBP) to reduce the mortality rate in septic shock. We have designed the EABPSS (Efficacy of Adaptive Blood Purification for Septic Shock) study to confirm whether adaptive blood purification (ABP) intervention could confer a clinical benefit.<h4>Methods and analysis</h4>In this multicentre, open-label, randomised controlled trial, we are recruiting a total of 276 patients with septic shock. Eligible patients who provide informed consent will be randomly assigned in a 1:1 ratio to either the control group or the intervention group. Patients in the control group will receive standard care according to the Surviving Sepsis Guidelines. Patients in the intervention group will receive two 6-hou","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T06:33:13.177Z","creation":"2026-06-05T03:07:06.352Z"},"accession":"S-EPMC12542525","cross_references":{"pubmed":["41120165"],"doi":["10.1136/bmjopen-2025-107311"]}}