{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lizcano-Perret B"],"funding":["Loterie Nationale (Belgium)","Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture (FRIA)","Fonds pour la Formation à la Recherche dans l&apos;Industrie et dans l&apos;Agriculture","Fonds De La Recherche Scientifique - FNRS","Loterie Nationale"],"pagination":["e0127525"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12548433"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["99(10)"],"pubmed_abstract":["Unrelated pathogens, including viruses and bacteria, use a common short linear motif (SLiM) to interact with cellular kinases of the RSK (p90 S6 ribosomal kinase) family. Such a \"DDVF\" (D/E-D/E-V-F) SLiM occurs in the leader (L) protein encoded by picornaviruses of the genus <i>Cardiovirus</i>, including Theiler's murine encephalomyelitis virus (TMEV), Boone cardiovirus (BCV), and Encephalomyocarditis virus (EMCV). The L-RSK complex is targeted to the nuclear pore, where RSK triggers FG-nucleoporins hyperphosphorylation, thereby causing nucleocytoplasmic trafficking disruption. In this work, we identified a second SLiM in the L proteins of TMEV and BCV, which enables the L-RSK complex to interact with RAE1 at the level of the nuclear pore complex. AlphaFold predictions suggest that the RAE"],"journal":["Journal of virology"],"pubmed_title":["The leader proteins of Theiler's virus and Boone cardiovirus use a combination of short linear motifs (SLiMs) to target RSK kinases to the nuclear pore complex."],"pmcid":["PMC12548433"],"funding_grant_id":["Fellowship","PDR T.0154.23","support via de Duve Institute","Aspirant","EOS IDs 30981113 and 40007527"],"pubmed_authors":["Sorgeloos F","Duflos C","Wavreil F","Lizcano-Perret B","Michiels T","Veinstein M","Milcamps R"],"additional_accession":[]},"is_claimable":false,"name":"The leader proteins of Theiler's virus and Boone cardiovirus use a combination of short linear motifs (SLiMs) to target RSK kinases to the nuclear pore complex.","description":"Unrelated pathogens, including viruses and bacteria, use a common short linear motif (SLiM) to interact with cellular kinases of the RSK (p90 S6 ribosomal kinase) family. Such a \"DDVF\" (D/E-D/E-V-F) SLiM occurs in the leader (L) protein encoded by picornaviruses of the genus <i>Cardiovirus</i>, including Theiler's murine encephalomyelitis virus (TMEV), Boone cardiovirus (BCV), and Encephalomyocarditis virus (EMCV). The L-RSK complex is targeted to the nuclear pore, where RSK triggers FG-nucleoporins hyperphosphorylation, thereby causing nucleocytoplasmic trafficking disruption. In this work, we identified a second SLiM in the L proteins of TMEV and BCV, which enables the L-RSK complex to interact with RAE1 at the level of the nuclear pore complex. AlphaFold predictions suggest that the RAE","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T04:37:29.691Z","creation":"2026-05-13T14:28:56.456Z"},"accession":"S-EPMC12548433","cross_references":{"pubmed":["40928249"],"doi":["10.1128/jvi.01275-25"]}}