biostudies-literatureLehmann ACentre Hospitalier Universitaire de GrenobleUniversité Joseph Fouriere0323542https://www.ebi.ac.uk/biostudies/studies/S-EPMC12548849biostudies-literatureUnknown20(10)<h4>Objective</h4>We aimed to develop a generic questionnaire for use in routine clinical practice to identify barriers and levers to medication adherence, particularly for patients with chronic disease, in order to implement targeted interventions.<h4>Materials and methods</h4>To generate items we conducted a narrative literature review and qualitatively analyzed semi-structured interviews of patients with chronic diseases (type 2 diabetes, chronic obstructive pulmonary disease and heart failure). Items were classified according to the five dimensions that influence medication adherence proposed by the WHO. Qualitative reduction of the number of items was conducted by a panel of experts. This long questionnaire was tested on ambulatory patients and analysis of responses enabled quantitatiPloS oneDevelopment of a self-administered questionnaire to identify levers and barriers to adherence to medication regimens for chronic disease: The QUILAM project.PMC12548849AGIR 2012DRCI 2013Roustit MMeslot CBardet JDAllenet BLehmann AGauchet AfalseDevelopment of a self-administered questionnaire to identify levers and barriers to adherence to medication regimens for chronic disease: The QUILAM project.<h4>Objective</h4>We aimed to develop a generic questionnaire for use in routine clinical practice to identify barriers and levers to medication adherence, particularly for patients with chronic disease, in order to implement targeted interventions.<h4>Materials and methods</h4>To generate items we conducted a narrative literature review and qualitatively analyzed semi-structured interviews of patients with chronic diseases (type 2 diabetes, chronic obstructive pulmonary disease and heart failure). Items were classified according to the five dimensions that influence medication adherence proposed by the WHO. Qualitative reduction of the number of items was conducted by a panel of experts. This long questionnaire was tested on ambulatory patients and analysis of responses enabled quantitati2025-01-01T00:00:00Z20252026-06-04T16:38:05.118Z2026-05-13T14:24:37.259ZS-EPMC125488494112951510.1371/journal.pone.0323542