biostudies-literatureJiao Ythe National Institutes of HealthMinistry of Finance of the People's Republic of China, China Nutritional Transition Cohort StudyNational Key R&D Program of China, Active Health and Aging Technologic Solutions Major Project-Study of Diet and Nutrition Assessment and Intervention TechnologyNICHD NIH HHS677-688https://www.ebi.ac.uk/biostudies/studies/S-EPMC12551791biostudies-literatureUnknown34(4)<h4>Background and objectives</h4>Life's Essential 8 (LE8) is a comprehensive indicator that evaluates cardiovascular health (CVH). There have been limited studies on the relationship between LE8 and hyperuricemia (HUA). This study explored the association and dose-response relationship between LE8 and HUA among elderly people in China.<h4>Methods and study design</h4>The subjects were the elderly aged 60 and over who participated in the China Health and Nutrition Survey (CHNS) in 2018. The definition of American Heart Association (AHA) was used to measure the score of LE8. Multivariate Logistic regression and restricted cubic spline (RCS) model were used to analyze the association and dose-response relationship between LE8 and HUA.<h4>Results</h4>A total of 4229 subjects were included, anAsia Pacific journal of clinical nutritionAssociation between Life's Essential 8 and hyperuricemia in the Chinese elderly.PMC12551791DK056350No. 2020YFC2006300NO. 13103110700015005R01-HD30880R24 HD050924R01-HD38700Li WDing GHong XJiang HJia XWang HJiao YZhang BWang ZWang LfalseAssociation between Life's Essential 8 and hyperuricemia in the Chinese elderly.<h4>Background and objectives</h4>Life's Essential 8 (LE8) is a comprehensive indicator that evaluates cardiovascular health (CVH). There have been limited studies on the relationship between LE8 and hyperuricemia (HUA). This study explored the association and dose-response relationship between LE8 and HUA among elderly people in China.<h4>Methods and study design</h4>The subjects were the elderly aged 60 and over who participated in the China Health and Nutrition Survey (CHNS) in 2018. The definition of American Heart Association (AHA) was used to measure the score of LE8. Multivariate Logistic regression and restricted cubic spline (RCS) model were used to analyze the association and dose-response relationship between LE8 and HUA.<h4>Results</h4>A total of 4229 subjects were included, an2025-01-01T00:00:00Z2025 Aug2026-06-05T04:43:50.331Z2026-05-13T14:29:08.146ZS-EPMC125517914073873410.6133/apjcn.202508_34(4).0018