{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chan D"],"funding":["Robert A. and Renee E. Belfer Family Foundation","The Dolby Family","Larry and Debora Hilibrand","NCATS NIH HHS","Gary Hua and Li Chen","Dave and Mary Wargo","Donald A. and Glenda G. Mattes","Alan and Susan Patricof","Joseph P. DiSabato and Nancy E. Sakamoto","James D. Cook, and the Nobert H. Hardner Foundation","Eduardo Eurnekian","Doris Duke Clinical Scientist Development Award","Picower Clinical Fellowship","Alex Hu and Anne Gao","Eleanor Schwartz Charitable Foundation","Che King Leo","David B. Emmes","Carol and Gene Ludwig Family Foundation","NIH Loan Repayment Program","Halis Family Foundation","Kathleen and Miguel Octavio","Elizabeth K. and Russell L. Siegelman","Ko Han Family","Lester Gimpelson","the Degroof-VM Foundation","Amy Wong and Calvin Chin","Chijen Lee","Freedom Together Foundation","Marc Haas Foundation"],"pagination":["e70792"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12552893"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(10)"],"pubmed_abstract":["<h4>Introduction</h4>We evaluated the long-term effects of daily 40 Hz (gamma frequency) audiovisual stimulation on cognition and biomarkers in five patients with mild Alzheimer's disease (AD).<h4>Methods</h4>Over 2 years, patients received 1-h daily stimulation. Electroencephalography (EEG) was used to assess neural entrainment; magnetic resonance imaging (MRI) measured brain volumes; actigraphy monitored activity patterns; neuropsychological tests evaluated cognition; and S-PLEX assay measured plasma pTau217.<h4>Results</h4>No adverse events occurred over the study period. Three female patients with late-onset AD (LOAD) retained strong EEG entrainment and showed less decline in Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), and Functional Assessment Scale (FAS) sco"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Gamma sensory stimulation in mild Alzheimer's dementia: An open-label extension study."],"pmcid":["PMC12552893"],"funding_grant_id":["UDIW8172","UL1 TR002541","15367"],"pubmed_authors":["Kitchener E","Hammerschlag B","Touroutoglou A","Arnold S","Firenze R","Brown EN","Quay MJ","Philips R","Jackson BL","Zheng M","Klerman EB","Kivisakk P","Suk HJ","Avalos VSF","Milman NP","Chan D","Aoki K","Dickerson BC","de Weck G","Boyden ES","Geigenmuller U","Ruiz E","Tsai LH","Brickhouse M","Becker A"],"additional_accession":[]},"is_claimable":false,"name":"Gamma sensory stimulation in mild Alzheimer's dementia: An open-label extension study.","description":"<h4>Introduction</h4>We evaluated the long-term effects of daily 40 Hz (gamma frequency) audiovisual stimulation on cognition and biomarkers in five patients with mild Alzheimer's disease (AD).<h4>Methods</h4>Over 2 years, patients received 1-h daily stimulation. Electroencephalography (EEG) was used to assess neural entrainment; magnetic resonance imaging (MRI) measured brain volumes; actigraphy monitored activity patterns; neuropsychological tests evaluated cognition; and S-PLEX assay measured plasma pTau217.<h4>Results</h4>No adverse events occurred over the study period. Three female patients with late-onset AD (LOAD) retained strong EEG entrainment and showed less decline in Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), and Functional Assessment Scale (FAS) sco","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-07-15T12:20:30.83Z","creation":"2026-07-04T03:13:19.544Z"},"accession":"S-EPMC12552893","cross_references":{"pubmed":["41137616"],"doi":["10.1002/alz.70792"]}}