biostudies-literatureUnknown14(17)Kubo S<h4>Background</h4>The association of outcomes with initial clip selection has not been investigated in patients undergoing transcatheter edge-to-edge repair with the MitraClip G4.<h4>Methods</h4>We analyzed 2257 patients receiving the MitraClip G4 according to the initial clip type: short (NT/NTW) versus long (XT/XTW) and narrow (NT/XT) versus wide (NTW/XTW). We performed a propensity-matched analysis of baseline anatomical features in patients with primary and secondary mitral regurgitation (MR).<h4>Results</h4>The proportions of the initial clip types were as follows: NT, 18.9%; NTW, 41.7%; XT, 5.1%; and XTW, 34.3%. The proportions of the MR severity ≤1+ at discharge and 1 year were not significantly different among the 4 clip types. The incidence of death or heart failure hospitalizatiJournal of the American Heart Associatione041907https://www.ebi.ac.uk/biostudies/studies/S-EPMC12553428biostudies-literatureReal-World Outcomes of the Initial Clip Selection for Transcatheter Edge-to-Edge Repair Using the MitraClip G4 From the Optimized Catheter Valvular Intervention-Mitral Registry.PMC12553428Miyahara KOtsuki HSaito TMiyahara DMaruyama MSaito MKawamura TNishio HOno SOhara HIrie YKurashima STsuru YOtsuka THosoda NDoi TDoi SYamada NYamada MYoshikawa MSaji MTsunamoto HShitan HOhara MOkabe KKuroda MOnuki KSobajima MTazawa DNaganuma TSasaki KShishido KOsakada KYanagisawa JNatsumeda MTsuruta HYamasaki KKoga MSato YHioki HKoyanagi CHorita ROkamatsu HKanno HIzumi YKobari YInagaki YUshijima RSato DHarano YTorii SHonda KHada TTsunaki TRyuzaki TInagaki MNakano KMiyamoto JImamura TKaneko TYamabe TNishio RShinada KFukunaga MKoyama YKo EMiyasaka MTakagi KSuenaga TOtake ROtani AShirai STsuchida YHoribata YYasuda MUeno HSugiyama YMaeda MNakamura NUeno YHayashida KAbe RKurita AOnoda HNakamura TKatagiri YHida YSakata SAihara KOnishi KIjichi TSatomi NNishiura NOmiya JHorinouchi HHorio ENagai TTokuda TTeng YMurakami TAmaki MMurakami YSuzuyama HWatanabe YIzumo MIshizu KOkazaki SIwata JNemoto YOkubo MShibahashi EFukushige SMiyazaki SMoriyama NMiyazaki MOkubo YNonaka HTabata MHiruma TSakakura TTabata HTerauchi KImai SOchiai TKitai TMoriizumi TKogure TKoike HYamanaka FHiguma TKamioka NKajino AKagase AMiura MKatayama THachinohe DShibata KKubo STanaka SYoshida AIsotani AIseki YImaeda STanaka KCerebral NTanaka JGonda YTanaka MKatsumata YKaihara TShimura TSaigan MFujita MOkamoto MKono HYoshida TKai TOkuno TArita RFujita KSone KOCEAN‐Mitral investigatorsKondo YArai MFukuda NKonami YKobayashi TTogashi DKuze YGoto SKobayashi KOhno YNishimura YNishikawa JKito KYamamoto KNakashima MYamamoto MAsami MTada NHasegawa SNakazawa GNakashima KSago MSakai KEnta YMunehisa YSoejima NBota HMiyashita HNoda SNakashima YMushiake KKodama KYamawaki MSakamoto TYuki HOuchi TKawahata RMorofuji TShimizu KMaruo TTakahashi TKato JYamaguchi RMizuno STakahashi NYamaguchi JTani TMurata RKagiyama NMatsumoto SHiguchi RMatsumoto TMiyoshi TMaekawara SOkada AHigami HHoriuchi YMiyawaki NKobayashi YShirakawa KArakawa MKuwata SNakagawa SKawamoto TfalseReal-World Outcomes of the Initial Clip Selection for Transcatheter Edge-to-Edge Repair Using the MitraClip G4 From the Optimized Catheter Valvular Intervention-Mitral Registry.<h4>Background</h4>The association of outcomes with initial clip selection has not been investigated in patients undergoing transcatheter edge-to-edge repair with the MitraClip G4.<h4>Methods</h4>We analyzed 2257 patients receiving the MitraClip G4 according to the initial clip type: short (NT/NTW) versus long (XT/XTW) and narrow (NT/XT) versus wide (NTW/XTW). We performed a propensity-matched analysis of baseline anatomical features in patients with primary and secondary mitral regurgitation (MR).<h4>Results</h4>The proportions of the initial clip types were as follows: NT, 18.9%; NTW, 41.7%; XT, 5.1%; and XTW, 34.3%. The proportions of the MR severity ≤1+ at discharge and 1 year were not significantly different among the 4 clip types. The incidence of death or heart failure hospitalizati2025-01-01T00:00:00Z2025 Sep2026-06-05T04:55:14.592Z2026-05-13T14:28:50.257ZS-EPMC125534284087902610.1161/JAHA.125.041907