biostudies-literatureUnknown14(17)Karimzad K<h4>Background</h4>Radiation therapy (RT) can cause cardiac implantable electronic device (CIED) malfunction, primarily reset. Given changes in RT and CIED technologies, large observational studies examining malfunction of contemporary CIEDs during modern-day RT are needed to guide clinical practice.<h4>Methods</h4>Electronic medical records of all consecutive patients with CIEDs who underwent RT at a large tertiary cancer center between January 2015 and January 2022 were reviewed. All patients had CIED interrogation before and after completion of RT. Device-related data and RT-specific variables were collected. Statistical analyses were performed at the RT course level.<h4>Results</h4>Over a period of 7 years, 677 patients (median age, 74 [interquartile range, 67. 8-79.2] years; 72% men) Journal of the American Heart Associatione042937https://www.ebi.ac.uk/biostudies/studies/S-EPMC12553441biostudies-literatureSafety of Contemporary Radiation Therapy in Patients With Cardiac Implantable Electronic Devices: Implications for Clinical Practice.PMC12553441Chauhan SWagner DPeeler CKarimzad KIliescu CShah STsai JChacon Portillo MDeswal AStrang AAmatullah ASong JVachhani SDougherty AHThakar DPollard-Larkin JKry SFMiller CMir Zaman Shah KKoduri ALopez DDurand JBKantharia BfalseSafety of Contemporary Radiation Therapy in Patients With Cardiac Implantable Electronic Devices: Implications for Clinical Practice.<h4>Background</h4>Radiation therapy (RT) can cause cardiac implantable electronic device (CIED) malfunction, primarily reset. Given changes in RT and CIED technologies, large observational studies examining malfunction of contemporary CIEDs during modern-day RT are needed to guide clinical practice.<h4>Methods</h4>Electronic medical records of all consecutive patients with CIEDs who underwent RT at a large tertiary cancer center between January 2015 and January 2022 were reviewed. All patients had CIED interrogation before and after completion of RT. Device-related data and RT-specific variables were collected. Statistical analyses were performed at the RT course level.<h4>Results</h4>Over a period of 7 years, 677 patients (median age, 74 [interquartile range, 67. 8-79.2] years; 72% men) 2025-01-01T00:00:00Z2025 Sep2026-06-05T04:54:41.633Z2026-05-13T14:28:46.517ZS-EPMC125534414084747910.1161/JAHA.125.042937