{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wolfgramm H"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["100489"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12554148"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["Mouse-adapted <i>Staphylococcus aureus</i> strains have become increasingly relevant in infection research thanks to their ability to better recapitulate clinical infection dynamics in mouse models. However, detailed characterisations required to establish a corresponding reference strain are still lacking. The mouse-adapted CC88 strain JSNZ appears to be an ideal candidate for a reference strain. Here, we present a comprehensive genomic and proteomic characterisation of JSNZ. Whole genome sequencing was performed using a combination of short and long reads. Proteomic profiling was conducted under standard laboratory conditions in TSB and RPMI during exponential and stationary growth using LC-MS/MS. The updated, closed genome sequence of JSNZ was integrated into <i>Aureo</i>Wiki for user-f"],"journal":["Current research in microbial sciences"],"pubmed_title":["Integrated genomic and proteomic analysis of the mouse-adapted &lt;i&gt;Staphylococcus aureus&lt;/i&gt; strain JSNZ."],"pmcid":["PMC12554148"],"funding_grant_id":["443535983"],"pubmed_authors":["Holtfreter S","Tebben J","Gesell Salazar M","Steil L","Mader U","Surmann K","Sura T","Volker U","Michalik S","Mehlan H","Bludau E","Reder A","Wolfgramm H","Busch LM","Hoffmuller T","Hagenau L"],"additional_accession":[]},"is_claimable":false,"name":"Integrated genomic and proteomic analysis of the mouse-adapted &lt;i&gt;Staphylococcus aureus&lt;/i&gt; strain JSNZ.","description":"Mouse-adapted <i>Staphylococcus aureus</i> strains have become increasingly relevant in infection research thanks to their ability to better recapitulate clinical infection dynamics in mouse models. However, detailed characterisations required to establish a corresponding reference strain are still lacking. The mouse-adapted CC88 strain JSNZ appears to be an ideal candidate for a reference strain. Here, we present a comprehensive genomic and proteomic characterisation of JSNZ. Whole genome sequencing was performed using a combination of short and long reads. Proteomic profiling was conducted under standard laboratory conditions in TSB and RPMI during exponential and stationary growth using LC-MS/MS. The updated, closed genome sequence of JSNZ was integrated into <i>Aureo</i>Wiki for user-f","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-07-16T15:12:47.514Z","creation":"2026-07-09T11:04:36.798Z"},"accession":"S-EPMC12554148","cross_references":{"pubmed":["41146725"],"doi":["10.1016/j.crmicr.2025.100489"]}}