{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luo D"],"funding":["Guangxi Natural Science Foundation","National Natural Science Foundation of China"],"pagination":["113671"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12554150"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(11)"],"pubmed_abstract":["Manganese (Mn) is an essential plant micronutrient but toxic at supra-optimal concentrations. Although nicotianamine (NA) biosynthesis is metal inducible, its specific role in Mn detoxification in wheat remains poorly characterized. Integrated transcriptomic and physiological analyses of Mn-tolerant (ET8, Carazinho) and Mn-sensitive (ES8, Egret) wheat near-isogenic lines and their parental cultivars under excess Mn revealed pronounced upregulation of genes encoding nicotianamine synthase (<i>TaNAS</i>), nicotianamine aminotransferase (<i>TaNAAT</i>), and putative Mn-NA transporters (<i>TaYSL2</i>, <i>TaYSL6</i>) in tolerant genotypes. This transcriptional response correlated with elevated NA accumulation in roots under Mn stress. Exogenous NA application enhanced Mn tolerance in hydroponic"],"journal":["iScience"],"pubmed_title":["Transcriptomic and physiological analyses revealed nicotianamine enhances wheat tolerance to excess manganese."],"pmcid":["PMC12554150"],"funding_grant_id":["2023GXNSFAA026445","32460463"],"pubmed_authors":["Zhang W","Dong D","Li Y","Usman M","Xing Y","Li Q","Pang F","Luo D"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic and physiological analyses revealed nicotianamine enhances wheat tolerance to excess manganese.","description":"Manganese (Mn) is an essential plant micronutrient but toxic at supra-optimal concentrations. Although nicotianamine (NA) biosynthesis is metal inducible, its specific role in Mn detoxification in wheat remains poorly characterized. Integrated transcriptomic and physiological analyses of Mn-tolerant (ET8, Carazinho) and Mn-sensitive (ES8, Egret) wheat near-isogenic lines and their parental cultivars under excess Mn revealed pronounced upregulation of genes encoding nicotianamine synthase (<i>TaNAS</i>), nicotianamine aminotransferase (<i>TaNAAT</i>), and putative Mn-NA transporters (<i>TaYSL2</i>, <i>TaYSL6</i>) in tolerant genotypes. This transcriptional response correlated with elevated NA accumulation in roots under Mn stress. Exogenous NA application enhanced Mn tolerance in hydroponic","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T05:14:51.659Z","creation":"2026-06-04T03:06:22.271Z"},"accession":"S-EPMC12554150","cross_references":{"pubmed":["41146715"],"doi":["10.1016/j.isci.2025.113671"]}}