{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Luo Q"],"pubmed_abstract":["<h4>Objective</h4>CD4<sup>+</sup>T cells are significant compositions of immune cells in rheumatoid arthritis (RA) and the aberrant function of CD4<sup>+</sup>T cells have been demonstrated to promote RA's progression. N6-methyladenosine (m6A) is a highly enriched modification found in CircRNAs. However, the role of m6A-methylated circRNA in regulation of CD4<sup>+</sup>T cells function in RA and its association with RA disease activity are presently unclear.<h4>Methods</h4>We used m6A-circRNA epitranscriptomic microarray analysis and m6A RNA immunocoprecipitation-quantitative polymerase chain reaction (MeRIP-qPCR) to screen and verify the differentially expressed m6A-methylated circRNAs in CD4<sup>+</sup>T cells from RA and HC.<h4>Results</h4>Many m6A-methylated circRNAs were differential"],"journal":["Journal of translational autoimmunity"],"pagination":["100326"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12554200"],"repository":["biostudies-literature"],"pubmed_title":["The significance of m6A-circFOXK2 in CD4&lt;sup&gt;+&lt;/sup&gt;T cells from patients with rheumatoid arthritis and circFOXK2 correlates with Th17 % and autophagy."],"pmcid":["PMC12554200"],"pubmed_authors":["Fu B","Wu Z","Luo Q","Li J","Huang Z","Wang S","Lan M","Fu P","Xiao Q"],"additional_accession":[]},"is_claimable":false,"name":"The significance of m6A-circFOXK2 in CD4&lt;sup&gt;+&lt;/sup&gt;T cells from patients with rheumatoid arthritis and circFOXK2 correlates with Th17 % and autophagy.","description":"<h4>Objective</h4>CD4<sup>+</sup>T cells are significant compositions of immune cells in rheumatoid arthritis (RA) and the aberrant function of CD4<sup>+</sup>T cells have been demonstrated to promote RA's progression. N6-methyladenosine (m6A) is a highly enriched modification found in CircRNAs. However, the role of m6A-methylated circRNA in regulation of CD4<sup>+</sup>T cells function in RA and its association with RA disease activity are presently unclear.<h4>Methods</h4>We used m6A-circRNA epitranscriptomic microarray analysis and m6A RNA immunocoprecipitation-quantitative polymerase chain reaction (MeRIP-qPCR) to screen and verify the differentially expressed m6A-methylated circRNAs in CD4<sup>+</sup>T cells from RA and HC.<h4>Results</h4>Many m6A-methylated circRNAs were differential","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-04T03:08:09.661Z","creation":"2026-06-04T03:06:11.417Z"},"accession":"S-EPMC12554200","cross_references":{"pubmed":["41146880"],"doi":["10.1016/j.jtauto.2025.100326"]}}