biostudies-literatureUnknown11Luo Q<h4>Objective</h4>CD4⁺T cells are significant compositions of immune cells in rheumatoid arthritis (RA) and the aberrant function of CD4⁺T cells have been demonstrated to promote RA's progression. N6-methyladenosine (m6A) is a highly enriched modification found in CircRNAs. However, the role of m6A-methylated circRNA in regulation of CD4⁺T cells function in RA and its association with RA disease activity are presently unclear.<h4>Methods</h4>We used m6A-circRNA epitranscriptomic microarray analysis and m6A RNA immunocoprecipitation-quantitative polymerase chain reaction (MeRIP-qPCR) to screen and verify the differentially expressed m6A-methylated circRNAs in CD4⁺T cells from RA and HC.<h4>Results</h4>Many m6A-methylated circRNAs were differentialJournal of translational autoimmunity100326https://www.ebi.ac.uk/biostudies/studies/S-EPMC12554200biostudies-literatureThe significance of m6A-circFOXK2 in CD4&lt;sup&gt;+&lt;/sup&gt;T cells from patients with rheumatoid arthritis and circFOXK2 correlates with Th17 % and autophagy.PMC12554200Fu BWu ZLuo QLi JHuang ZWang SLan MFu PXiao QfalseThe significance of m6A-circFOXK2 in CD4&lt;sup&gt;+&lt;/sup&gt;T cells from patients with rheumatoid arthritis and circFOXK2 correlates with Th17 % and autophagy.<h4>Objective</h4>CD4⁺T cells are significant compositions of immune cells in rheumatoid arthritis (RA) and the aberrant function of CD4⁺T cells have been demonstrated to promote RA's progression. N6-methyladenosine (m6A) is a highly enriched modification found in CircRNAs. However, the role of m6A-methylated circRNA in regulation of CD4⁺T cells function in RA and its association with RA disease activity are presently unclear.<h4>Methods</h4>We used m6A-circRNA epitranscriptomic microarray analysis and m6A RNA immunocoprecipitation-quantitative polymerase chain reaction (MeRIP-qPCR) to screen and verify the differentially expressed m6A-methylated circRNAs in CD4⁺T cells from RA and HC.<h4>Results</h4>Many m6A-methylated circRNAs were differential2025-01-01T00:00:00Z2025 Dec2026-06-04T03:08:09.661Z2026-06-04T03:06:11.417ZS-EPMC125542004114688010.1016/j.jtauto.2025.100326