biostudies-literatureUnknown14(9)Wang L<h4>Background</h4>YTHDF1, a regulator of N6-methyladenosine (m6A) modification, participates in regulating the pathological mechanism of cancer, but its role in lung adenocarcinoma (LUAD) remains in need of deeper elucidation. This study aimed to uncover potential molecular characteristics of YTHDF1 in LUAD, establishing a conceptual foundation for disease management.<h4>Methods</h4>YTHDF1 expression was analyzed in LUAD using The Cancer Genome Atlas (TCGA) data, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting. A competitive endogenous RNA (ceRNA) network was established to explore molecular interactions, and LUAD was categorized based on YTHDF1 expression levels. Survival rates and immune cell infiltration were compared between categories. Genes related tTranslational cancer research5884-5905https://www.ebi.ac.uk/biostudies/studies/S-EPMC12554477biostudies-literatureThe role of YTHDF1 in the diagnosis and prognosis of lung adenocarcinoma and its inhibitor LY-411575 in the targeted intervention of lung adenocarcinoma growth.PMC12554477Huang SYao ZYang ZYang YLi CHan LJia DWang CFan BWang LfalseThe role of YTHDF1 in the diagnosis and prognosis of lung adenocarcinoma and its inhibitor LY-411575 in the targeted intervention of lung adenocarcinoma growth.<h4>Background</h4>YTHDF1, a regulator of N6-methyladenosine (m6A) modification, participates in regulating the pathological mechanism of cancer, but its role in lung adenocarcinoma (LUAD) remains in need of deeper elucidation. This study aimed to uncover potential molecular characteristics of YTHDF1 in LUAD, establishing a conceptual foundation for disease management.<h4>Methods</h4>YTHDF1 expression was analyzed in LUAD using The Cancer Genome Atlas (TCGA) data, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting. A competitive endogenous RNA (ceRNA) network was established to explore molecular interactions, and LUAD was categorized based on YTHDF1 expression levels. Survival rates and immune cell infiltration were compared between categories. Genes related t2025-01-01T00:00:00Z2025 Sep2026-06-05T07:49:05.852Z2026-05-14T03:12:40.716ZS-EPMC125544774115822610.21037/tcr-2025-713