{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alvarez-Arguedas S"],"funding":["National Institute of Neurological Disorders and Stroke","National Institute of Allergy and Infectious Diseases Division of Intramural Research","NIAID NIH HHS","NCI NIH HHS","NINDS NIH HHS","National Institutes of Health"],"pagination":["1199-1217"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12556950"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(5)"],"pubmed_abstract":["The nasal, oropharyngeal, and bronchial mucosa are primary contact points for airborne pathogens like Mycobacterium tuberculosis (Mtb), SARS-CoV-2, and influenza virus. While mucosal surfaces can function as both entry points and barriers to infection, mucosa-associated lymphoid tissues (MALT) facilitate early immune responses to mucosal antigens. MALT contains a variety of specialized epithelial cells, including a rare cell type called a microfold cell (M cell) that functions to transport apical antigens to basolateral antigen-presenting cells, a crucial step in the initiation of mucosal immunity. M cells have been extensively characterized in the gastrointestinal (GI) tract in murine and human models. However, the precise development and functions of human airway M cells are unknown. Her"],"journal":["Mucosal immunology"],"pubmed_title":["Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells."],"pmcid":["PMC12556950"],"funding_grant_id":["U19 NS130608","U01 AI125939","R01 AI184584","P30 CA142543"],"pubmed_authors":["Alvarez-Arguedas S","Mazhar K","Sankaranarayanan I","Shiloh MU","Lafin JT","Wangzhou A","Mitchell RB","Gaona G","Price TJ"],"additional_accession":[]},"is_claimable":false,"name":"Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells.","description":"The nasal, oropharyngeal, and bronchial mucosa are primary contact points for airborne pathogens like Mycobacterium tuberculosis (Mtb), SARS-CoV-2, and influenza virus. While mucosal surfaces can function as both entry points and barriers to infection, mucosa-associated lymphoid tissues (MALT) facilitate early immune responses to mucosal antigens. MALT contains a variety of specialized epithelial cells, including a rare cell type called a microfold cell (M cell) that functions to transport apical antigens to basolateral antigen-presenting cells, a crucial step in the initiation of mucosal immunity. M cells have been extensively characterized in the gastrointestinal (GI) tract in murine and human models. However, the precise development and functions of human airway M cells are unknown. Her","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-06T15:05:02.934Z","creation":"2026-06-01T03:10:41.852Z"},"accession":"S-EPMC12556950","cross_references":{"pubmed":["40721095"],"doi":["10.1016/j.mucimm.2025.07.006"]}}