{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Kara B"],"pubmed_abstract":["Soluble tau oligomeric assemblies display neurotoxic properties and may provide a pathogenic link between neurofibrillary tangle evolution and selective neuronal vulnerability in Alzheimer's disease (AD). However, the precise molecular and cellular pathways mediating tau oligomer toxicity are unclear. We combined single-neuron laser capture microdissection with custom microarrays to investigate differences in the molecular signatures of basal forebrain neurons within the nucleus basalis of Meynert (nbM) labeled for p75<sup>NTR</sup>, a cholinergic cell marker, or dual-labeled for p75<sup>NTR</sup> and TOC1, a tau oligomer marker. Tissue was obtained postmortem from Rush Religious Orders Study participants who died with an antemortem clinical diagnosis of no cognitive impairment (NCI), mild"],"journal":["Acta neuropathologica communications"],"pagination":["218"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12557935"],"repository":["biostudies-literature"],"pubmed_title":["Neuronal gene profiling of tau oligomer-bearing cholinergic nucleus basalis neurons during the onset of Alzheimer's disease."],"pmcid":["PMC12557935"],"pubmed_authors":["Kara B","Kanaan NM","Beck JS","Mufson EJ","Fu Z","Hickey SL","Ginsberg SD","Counts SE"],"additional_accession":[]},"is_claimable":false,"name":"Neuronal gene profiling of tau oligomer-bearing cholinergic nucleus basalis neurons during the onset of Alzheimer's disease.","description":"Soluble tau oligomeric assemblies display neurotoxic properties and may provide a pathogenic link between neurofibrillary tangle evolution and selective neuronal vulnerability in Alzheimer's disease (AD). However, the precise molecular and cellular pathways mediating tau oligomer toxicity are unclear. We combined single-neuron laser capture microdissection with custom microarrays to investigate differences in the molecular signatures of basal forebrain neurons within the nucleus basalis of Meynert (nbM) labeled for p75<sup>NTR</sup>, a cholinergic cell marker, or dual-labeled for p75<sup>NTR</sup> and TOC1, a tau oligomer marker. Tissue was obtained postmortem from Rush Religious Orders Study participants who died with an antemortem clinical diagnosis of no cognitive impairment (NCI), mild","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-14T03:25:13.745Z","creation":"2026-05-14T03:12:40.994Z"},"accession":"S-EPMC12557935","cross_references":{"pubmed":["41146342"],"doi":["10.1186/s40478-025-02080-2"]}}