{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["82(11)"],"submitter":["Salvado G"],"pubmed_abstract":["<h4>Importance</h4>Advances in Alzheimer disease (AD) have shifted research focus to earlier disease stages, necessitating more scalable approaches to identify cognitively unimpaired individuals with amyloid β (Aβ) pathology.<h4>Objective</h4>To assess the utility of plasma phosphorylated tau 217 (p-tau217) for classifying Aβ status in cognitively unimpaired individuals, both as a stand-alone test and in a 2-step approach where positive plasma results were confirmed using a second modality (Aβ positron emission tomography [PET] or cerebrospinal fluid [CSF]).<h4>Design, setting, and participants</h4>This cross-sectional cohort study used data collected between June 2009 and March 2024. We included 2916 cognitively unimpaired participants from 12 international independent observational cohor"],"journal":["JAMA neurology"],"pagination":["1122-1134"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12558403"],"repository":["biostudies-literature"],"pubmed_title":["Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease."],"pmcid":["PMC12558403"],"pubmed_authors":["Breitner JCS","Canas Martinez A","Crawford K","Bernard M","Di Benedetto J","Poirier J","Saito N","Strong J","Aquite Aguilar R","Gispert JD","Miller MJ","Carrillo M","Karlawish J","Villemagne V","DeCarli C","Okonkwo O","Gunter J","Parkins S","Lee VMY","Montine T","Taylor-Reinwald L","Fidell A","Frank R","Reyes C","Hansson O","Jenkins C","Reyes D","Nudelman K","Matoush L","Moore-Weiss J","Tosun D","Gonzalez H","Fletcher E","Lee EB","Robison J","van der Flier WM","Schwarz C","Malone I","Ayo O","Neu S","Khachaturian Z","Menchon Diaz T","Conti C","Nir TM","Risacher SL","Coomans EM","Gonzalez-Escalante A","Aisen P","Clanton T","Webb C","Alcolea D","Guzman V","Harkins K","Vilanova Jaramillo M","Glittenberg M","Talavera S","Brum WS","Zimmerman C","Craft H","Jo T","Apostolova LG","Brugulat-Serrat A","Borowski B","Fockler J","Landau S","Dore V","Ajayi A","Koeppe RA","Ashford M","Weisensel T","Rossi Chen S","Green RC","Perrin R","Amaza H","Pascual M","Barnes L","Largent E","Sala Vila A","Petersen RC","Hergesheimer L","Adem Hussen K","Solsona Harster L","Bernhardt H","Nho K","Franklin E","Ryan L","Choe M","Reid R","Adegoke O","Nosheny R","Schindler SE","Rivera-Mindt M","Badawy M","Ogwang S","Rafii M","Minguillon C","Pradas Mendez S","Morris J","Erickson C","Brylska M","Flenniken D","Salvado G","Jackson J","Jagust W","Saykin AJ","Magana F","Ros Freixedes L","Faber K","Thompson P","Iglesias Gamaz L","Benzinger TLS","Kubo Germano K","Vemuri P","Petersen R","Fox NC","Lacy K","Suarez-Calvet M","Shen L","Kaddurah-Daouk R","LoPresti B","Hoang I","Wan Y","Senjem M","Genius Serra P","Thal L","Jin C","Silverberg N","Masliah E","Salazar J","Knaack A","Yushkevich PA","Shaffer E","Pizzola J","Sachdev P","Soteras Prat A","Stomrud E","Ossenkoppele R","Marne Alvarez P","Walter S","Grill J","Mattsson-Carlgren N","Palacios E","Molchan S","Beteta Gorriti A","Cairns NJ","Huesa Rodriguez G","Buckholtz N","Toga AW","Polo Ballester A","Rowe CC","Thomas L","Johnson SC","Masterman D","Villeneuve S","Cabrera Y","Huguet Ninou J","Felmlee J","Boatwright V","Mahboubi P","Foroud TM","Hernandez Penas L","Rosa-Neto P","Bali D","Weiner M","Snyder PJ","Pichet Binette A","Raman R","Rodriguez-Fernandez B","Teunissen CE","Forghanian-Arani A","Truran Sacrey D","Beckett L","Hedberg C","Jack CR","Kwang W","Fuentes Julian S","Therriault J","Rahmouni N","Janelidze S","Palmqvist S","ADNI, ALFA, and PREVENT-AD Study Groups","Seng Thao M","Kachaturian Z","Cacciaglia R","Dolado AO","Ho C","Potter Z","Fortea J","Rabinovici G","Potter W","Korecka M","Harvey D","Blennow K","Ward C","Diaz A","Das S","Drake E","Kormos A","Del Campo Milan M","Dominguez Iglesias R","Vilor-Tejedor N","Feizpour A","Baillet S","Baril AA","Hsiao JK","Jahanshad N","Trojanowki JQ","Knezevic I","Canals Gispert L","Donohue M","Jimenez G","Smith S","Thomopoulos SI","Shaw LM","Kantarci K"],"additional_accession":[]},"is_claimable":false,"name":"Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease.","description":"<h4>Importance</h4>Advances in Alzheimer disease (AD) have shifted research focus to earlier disease stages, necessitating more scalable approaches to identify cognitively unimpaired individuals with amyloid β (Aβ) pathology.<h4>Objective</h4>To assess the utility of plasma phosphorylated tau 217 (p-tau217) for classifying Aβ status in cognitively unimpaired individuals, both as a stand-alone test and in a 2-step approach where positive plasma results were confirmed using a second modality (Aβ positron emission tomography [PET] or cerebrospinal fluid [CSF]).<h4>Design, setting, and participants</h4>This cross-sectional cohort study used data collected between June 2009 and March 2024. We included 2916 cognitively unimpaired participants from 12 international independent observational cohor","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-05T12:46:20.449Z","creation":"2026-05-17T03:07:49.497Z"},"accession":"S-EPMC12558403","cross_references":{"pubmed":["40952756"],"doi":["10.1001/jamaneurol.2025.3217"]}}