biostudies-literatureUnknown82(11)Salvado G<h4>Importance</h4>Advances in Alzheimer disease (AD) have shifted research focus to earlier disease stages, necessitating more scalable approaches to identify cognitively unimpaired individuals with amyloid β (Aβ) pathology.<h4>Objective</h4>To assess the utility of plasma phosphorylated tau 217 (p-tau217) for classifying Aβ status in cognitively unimpaired individuals, both as a stand-alone test and in a 2-step approach where positive plasma results were confirmed using a second modality (Aβ positron emission tomography [PET] or cerebrospinal fluid [CSF]).<h4>Design, setting, and participants</h4>This cross-sectional cohort study used data collected between June 2009 and March 2024. We included 2916 cognitively unimpaired participants from 12 international independent observational cohorJAMA neurology1122-1134https://www.ebi.ac.uk/biostudies/studies/S-EPMC12558403biostudies-literaturePlasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease.PMC12558403Breitner JCSCanas Martinez ACrawford KBernard MDi Benedetto JPoirier JSaito NStrong JAquite Aguilar RGispert JDMiller MJCarrillo MKarlawish JVillemagne VDeCarli COkonkwo OGunter JParkins SLee VMYMontine TTaylor-Reinwald LFidell AFrank RReyes CHansson OJenkins CReyes DNudelman KMatoush LMoore-Weiss JTosun DGonzalez HFletcher ELee EBRobison Jvan der Flier WMSchwarz CMalone IAyo ONeu SKhachaturian ZMenchon Diaz TConti CNir TMRisacher SLCoomans EMGonzalez-Escalante AAisen PClanton TWebb CAlcolea DGuzman VHarkins KVilanova Jaramillo MGlittenberg MTalavera SBrum WSZimmerman CCraft HJo TApostolova LGBrugulat-Serrat ABorowski BFockler JLandau SDore VAjayi AKoeppe RAAshford MWeisensel TRossi Chen SGreen RCPerrin RAmaza HPascual MBarnes LLargent ESala Vila APetersen RCHergesheimer LAdem Hussen KSolsona Harster LBernhardt HNho KFranklin ERyan LChoe MReid RAdegoke ONosheny RSchindler SERivera-Mindt MBadawy MOgwang SRafii MMinguillon CPradas Mendez SMorris JErickson CBrylska MFlenniken DSalvado GJackson JJagust WSaykin AJMagana FRos Freixedes LFaber KThompson PIglesias Gamaz LBenzinger TLSKubo Germano KVemuri PPetersen RFox NCLacy KSuarez-Calvet MShen LKaddurah-Daouk RLoPresti BHoang IWan YSenjem MGenius Serra PThal LJin CSilverberg NMasliah ESalazar JKnaack AYushkevich PAShaffer EPizzola JSachdev PSoteras Prat AStomrud EOssenkoppele RMarne Alvarez PWalter SGrill JMattsson-Carlgren NPalacios EMolchan SBeteta Gorriti ACairns NJHuesa Rodriguez GBuckholtz NToga AWPolo Ballester ARowe CCThomas LJohnson SCMasterman DVilleneuve SCabrera YHuguet Ninou JFelmlee JBoatwright VMahboubi PForoud TMHernandez Penas LRosa-Neto PBali DWeiner MSnyder PJPichet Binette ARaman RRodriguez-Fernandez BTeunissen CEForghanian-Arani ATruran Sacrey DBeckett LHedberg CJack CRKwang WFuentes Julian STherriault JRahmouni NJanelidze SPalmqvist SADNI, ALFA, and PREVENT-AD Study GroupsSeng Thao MKachaturian ZCacciaglia RDolado AOHo CPotter ZFortea JRabinovici GPotter WKorecka MHarvey DBlennow KWard CDiaz ADas SDrake EKormos ADel Campo Milan MDominguez Iglesias RVilor-Tejedor NFeizpour ABaillet SBaril AAHsiao JKJahanshad NTrojanowki JQKnezevic ICanals Gispert LDonohue MJimenez GSmith SThomopoulos SIShaw LMKantarci KfalsePlasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease.<h4>Importance</h4>Advances in Alzheimer disease (AD) have shifted research focus to earlier disease stages, necessitating more scalable approaches to identify cognitively unimpaired individuals with amyloid β (Aβ) pathology.<h4>Objective</h4>To assess the utility of plasma phosphorylated tau 217 (p-tau217) for classifying Aβ status in cognitively unimpaired individuals, both as a stand-alone test and in a 2-step approach where positive plasma results were confirmed using a second modality (Aβ positron emission tomography [PET] or cerebrospinal fluid [CSF]).<h4>Design, setting, and participants</h4>This cross-sectional cohort study used data collected between June 2009 and March 2024. We included 2916 cognitively unimpaired participants from 12 international independent observational cohor2025-01-01T00:00:00Z2025 Nov2026-06-05T12:46:20.449Z2026-05-17T03:07:49.497ZS-EPMC125584034095275610.1001/jamaneurol.2025.3217