{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(10)"],"submitter":["Li J"],"pubmed_abstract":["<h4>Background</h4>Diabetic cardiomyopathy (DCM) represents a distinct myocardial pathology arising from chronic diabetic metabolic disturbances, characterized by progressive structural and functional abnormalities that frequently culminate in heart failure. Cuproptosis, a novel form of cell death, is highly linked to mitochondrial metabolism and mediated by protein lipoylation. However, studies are limited on the clinical significance of cuproptosis-related genes (CRGs) in DCM. Therefore, it is helpful to identify CRGs involved in DCM and explore their expression and molecular mechanisms.<h4>Methods</h4>We downloaded three datasets of DCM from the GEO database and a set of cuproptosis-related genes with 176 genes. Following the identification of the differentially expressed cuproptosis-re"],"journal":["PloS one"],"pagination":["e0328512"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12558461"],"repository":["biostudies-literature"],"pubmed_title":["Comprehensive analysis of cuproptosis-related genes in diabetic cardiomyopathy."],"pmcid":["PMC12558461"],"pubmed_authors":["Li X","Li J","Zhang H","Zhang M","Hao C","Duan X"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive analysis of cuproptosis-related genes in diabetic cardiomyopathy.","description":"<h4>Background</h4>Diabetic cardiomyopathy (DCM) represents a distinct myocardial pathology arising from chronic diabetic metabolic disturbances, characterized by progressive structural and functional abnormalities that frequently culminate in heart failure. Cuproptosis, a novel form of cell death, is highly linked to mitochondrial metabolism and mediated by protein lipoylation. However, studies are limited on the clinical significance of cuproptosis-related genes (CRGs) in DCM. Therefore, it is helpful to identify CRGs involved in DCM and explore their expression and molecular mechanisms.<h4>Methods</h4>We downloaded three datasets of DCM from the GEO database and a set of cuproptosis-related genes with 176 genes. Following the identification of the differentially expressed cuproptosis-re","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-05T05:30:57.369Z","creation":"2026-05-13T14:29:22.539Z"},"accession":"S-EPMC12558461","cross_references":{"pubmed":["41144543"],"doi":["10.1371/journal.pone.0328512"]}}