biostudies-literatureUnknown20(10)Li J<h4>Background</h4>Diabetic cardiomyopathy (DCM) represents a distinct myocardial pathology arising from chronic diabetic metabolic disturbances, characterized by progressive structural and functional abnormalities that frequently culminate in heart failure. Cuproptosis, a novel form of cell death, is highly linked to mitochondrial metabolism and mediated by protein lipoylation. However, studies are limited on the clinical significance of cuproptosis-related genes (CRGs) in DCM. Therefore, it is helpful to identify CRGs involved in DCM and explore their expression and molecular mechanisms.<h4>Methods</h4>We downloaded three datasets of DCM from the GEO database and a set of cuproptosis-related genes with 176 genes. Following the identification of the differentially expressed cuproptosis-rePloS onee0328512https://www.ebi.ac.uk/biostudies/studies/S-EPMC12558461biostudies-literatureComprehensive analysis of cuproptosis-related genes in diabetic cardiomyopathy.PMC12558461Li XLi JZhang HZhang MHao CDuan XfalseComprehensive analysis of cuproptosis-related genes in diabetic cardiomyopathy.<h4>Background</h4>Diabetic cardiomyopathy (DCM) represents a distinct myocardial pathology arising from chronic diabetic metabolic disturbances, characterized by progressive structural and functional abnormalities that frequently culminate in heart failure. Cuproptosis, a novel form of cell death, is highly linked to mitochondrial metabolism and mediated by protein lipoylation. However, studies are limited on the clinical significance of cuproptosis-related genes (CRGs) in DCM. Therefore, it is helpful to identify CRGs involved in DCM and explore their expression and molecular mechanisms.<h4>Methods</h4>We downloaded three datasets of DCM from the GEO database and a set of cuproptosis-related genes with 176 genes. Following the identification of the differentially expressed cuproptosis-re2025-01-01T00:00:00Z20252026-06-05T05:30:57.369Z2026-05-13T14:29:22.539ZS-EPMC125584614114454310.1371/journal.pone.0328512