biostudies-literatureUnknown12Di Minno A<h4>Introduction</h4>Impaired fasting glycemia (IFG) puts carriers at a significantly higher risk of developing type 2 diabetes and cardiovascular disease. Lifestyle changes, such as increased physical activity and a healthy diet rich in fiber and low in sugar, can often reverse prediabetes and significantly reduce the risk of progressing to type 2 diabetes metabolic disorders, especially diabetes (1).<h4>Methods</h4>This randomized clinical trial aims to evaluate the efficacy and tolerability of a food supplement (FS) containing <i>Citrus limon</i> L. Osbeck and <i>Vitis vinifera</i> L. extracts, hesperidin from <i>Citrus sinensis</i> L. Osbeck, and chromium, in individuals with impaired fasting blood glucose , with the final goal of investigating whether the use of a combination of ingreFrontiers in nutrition1671102https://www.ebi.ac.uk/biostudies/studies/S-EPMC12558782biostudies-literatureImpact of a food supplement containing &lt;i&gt;Citrus limon&lt;/i&gt; L. Osbeck and &lt;i&gt;Vitis vinifera&lt;/i&gt; L. extracts, hesperidin and chromium in combination with an isocaloric diet on glucose and lipid metabolism in subjects with impaired fasting blood glucose: a single-center, controlled, randomized, parallel-arm, double-blind clinical trial.PMC12558782Borromeo LSantonastaso SPiccinocchi REl-Seedi HGreco AXiao XSacchi RDe Lellis LFBaldi ABuccato DGCerqua ADaglia MMorone MVUllah HLarsen DSRiccioni CVPiccinocchi GDi Minno AfalseImpact of a food supplement containing &lt;i&gt;Citrus limon&lt;/i&gt; L. Osbeck and &lt;i&gt;Vitis vinifera&lt;/i&gt; L. extracts, hesperidin and chromium in combination with an isocaloric diet on glucose and lipid metabolism in subjects with impaired fasting blood glucose: a single-center, controlled, randomized, parallel-arm, double-blind clinical trial.<h4>Introduction</h4>Impaired fasting glycemia (IFG) puts carriers at a significantly higher risk of developing type 2 diabetes and cardiovascular disease. Lifestyle changes, such as increased physical activity and a healthy diet rich in fiber and low in sugar, can often reverse prediabetes and significantly reduce the risk of progressing to type 2 diabetes metabolic disorders, especially diabetes (1).<h4>Methods</h4>This randomized clinical trial aims to evaluate the efficacy and tolerability of a food supplement (FS) containing <i>Citrus limon</i> L. Osbeck and <i>Vitis vinifera</i> L. extracts, hesperidin from <i>Citrus sinensis</i> L. Osbeck, and chromium, in individuals with impaired fasting blood glucose , with the final goal of investigating whether the use of a combination of ingre2025-01-01T00:00:00Z20252026-05-15T03:17:47.341Z2026-05-15T03:11:58.328ZS-EPMC125587824116436010.3389/fnut.2025.1671102