{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Mohammadiaria M"],"pubmed_abstract":["Environmental stressors such as radiation, pH shifts, temperature variations, and electromagnetic fields can trigger intracellular oxidative stress, upregulating voltage-gated ion channel (VGIC) gene expression. This paper presents a hybrid modeling framework integrating Hodgkin-Huxley-based electrophysiological simulations with redox-sensitive transcriptional feedback to investigate how reactive oxygen species (ROS) modulate calcium signaling and drive electrophysiological reprogramming. In healthy epithelial cells (MCF-10A), sustained oxidative perturbations induce non-voltage-gated calcium influx, mitochondrial ROS generation, and VGIC transcription, shifting membrane potential from non-excitable to excitable states. Repeated ROS or thermal pulses promote progressive VGIC expression, de"],"journal":["NPJ systems biology and applications"],"pagination":["119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12559232"],"repository":["biostudies-literature"],"pubmed_title":["ROS-induced voltage-gated ion channel expression and electrophysiological remodeling in malignant human cells."],"pmcid":["PMC12559232"],"pubmed_authors":["Mohammadiaria M"],"additional_accession":[]},"is_claimable":false,"name":"ROS-induced voltage-gated ion channel expression and electrophysiological remodeling in malignant human cells.","description":"Environmental stressors such as radiation, pH shifts, temperature variations, and electromagnetic fields can trigger intracellular oxidative stress, upregulating voltage-gated ion channel (VGIC) gene expression. This paper presents a hybrid modeling framework integrating Hodgkin-Huxley-based electrophysiological simulations with redox-sensitive transcriptional feedback to investigate how reactive oxygen species (ROS) modulate calcium signaling and drive electrophysiological reprogramming. In healthy epithelial cells (MCF-10A), sustained oxidative perturbations induce non-voltage-gated calcium influx, mitochondrial ROS generation, and VGIC transcription, shifting membrane potential from non-excitable to excitable states. Repeated ROS or thermal pulses promote progressive VGIC expression, de","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-07-15T11:59:25.207Z","creation":"2026-07-04T03:12:40.63Z"},"accession":"S-EPMC12559232","cross_references":{"pubmed":["41145509"],"doi":["10.1038/s41540-025-00595-x"]}}