{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["88(10)"],"submitter":["Lopez-Sampedro E"],"pubmed_abstract":["Sea cucumbers (Holothuriidae) are highly valued in traditional medicine and are recognized for their diverse bioactivities, which are largely attributed to their rich triterpene glycoside content. Given that <i>Holothuria inornata</i> was chemically uncharacterized, this study describes the bioassay-guided isolation of these compounds. Nine sulfated saponins were purified, and their structures were elucidated using UPLC-QTOF/HR-ESI-MS<sup><i>n</i></sup> and comprehensive NMR spectroscopy. Six new compounds were identified, including inornatosides A-C (<b>1</b>-<b>3</b>) and 22<i>R</i>-holothurin B (<b>6</b>), all possessing a holostane-type aglycone, alongside inornatosides D (<b>4</b>) and E (<b>5</b>), which feature unique aglycones. Cytotoxic assays revealed that inornatoside B (<b>2</b"],"journal":["Journal of natural products"],"pagination":["2372-2382"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12560079"],"repository":["biostudies-literature"],"pubmed_title":["Cytotoxic Triterpene Glycosides from Mexican Sea Cucumber &lt;i&gt;Holothuria inornata&lt;/i&gt;."],"pmcid":["PMC12560079"],"pubmed_authors":["Lopez-Sampedro E","Arreguin-Espinosa R","Simonet AM"],"additional_accession":[]},"is_claimable":false,"name":"Cytotoxic Triterpene Glycosides from Mexican Sea Cucumber &lt;i&gt;Holothuria inornata&lt;/i&gt;.","description":"Sea cucumbers (Holothuriidae) are highly valued in traditional medicine and are recognized for their diverse bioactivities, which are largely attributed to their rich triterpene glycoside content. Given that <i>Holothuria inornata</i> was chemically uncharacterized, this study describes the bioassay-guided isolation of these compounds. Nine sulfated saponins were purified, and their structures were elucidated using UPLC-QTOF/HR-ESI-MS<sup><i>n</i></sup> and comprehensive NMR spectroscopy. Six new compounds were identified, including inornatosides A-C (<b>1</b>-<b>3</b>) and 22<i>R</i>-holothurin B (<b>6</b>), all possessing a holostane-type aglycone, alongside inornatosides D (<b>4</b>) and E (<b>5</b>), which feature unique aglycones. Cytotoxic assays revealed that inornatoside B (<b>2</b","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T08:49:48.391Z","creation":"2026-05-14T03:12:33.772Z"},"accession":"S-EPMC12560079","cross_references":{"pubmed":["40976948"],"doi":["10.1021/acs.jnatprod.5c00716"]}}