{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(48)"],"submitter":["Canh Pham E"],"pubmed_abstract":["Twenty symmetrical chlorophenylamino-<i>s</i>-triazine derivatives were designed and synthesized by reflux (RF) and microwave-assisted (MW) methods. The MW method achieved superior yields (88-95%) in less time (15-30 min) compared to RF (78-86%, 12-24 h), particularly for 3-Cl and 3,4-diCl derivatives with piperidine or diethylamine, due to rapid, uniform heating, enhancing nucleophilic substitution and minimizing side reactions. In particular, compounds 2c (IC<sub>50</sub> = 4.14 μM for MCF7, 7.87 μM for C26), 3c (IC<sub>50</sub> = 4.98 μM for MCF7, 3.05 μM for C26), and 4c (IC<sub>50</sub> = 6.85 μM for MCF7, 1.71 μM for C26) exhibited potent cytotoxic activity with 4c (2,4-diCl, pyrrolidine) surpassing paclitaxel (IC<sub>50</sub> = 2.30 μM for C26), and 3c (3,4-diCl, pyrrolidine) rivali"],"journal":["RSC advances"],"pagination":["41169-41188"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12560096"],"repository":["biostudies-literature"],"pubmed_title":["Design, synthesis, &lt;i&gt;in vitro&lt;/i&gt; cytotoxic activity, and &lt;i&gt;in silico&lt;/i&gt; studies of symmetrical chlorophenylamino-&lt;i&gt;s&lt;/i&gt;-triazine derivatives."],"pmcid":["PMC12560096"],"pubmed_authors":["Canh Pham E","Nguyen ST","Truong TN","Thi Le KA","Thi Hong Do T"],"additional_accession":[]},"is_claimable":false,"name":"Design, synthesis, &lt;i&gt;in vitro&lt;/i&gt; cytotoxic activity, and &lt;i&gt;in silico&lt;/i&gt; studies of symmetrical chlorophenylamino-&lt;i&gt;s&lt;/i&gt;-triazine derivatives.","description":"Twenty symmetrical chlorophenylamino-<i>s</i>-triazine derivatives were designed and synthesized by reflux (RF) and microwave-assisted (MW) methods. The MW method achieved superior yields (88-95%) in less time (15-30 min) compared to RF (78-86%, 12-24 h), particularly for 3-Cl and 3,4-diCl derivatives with piperidine or diethylamine, due to rapid, uniform heating, enhancing nucleophilic substitution and minimizing side reactions. In particular, compounds 2c (IC<sub>50</sub> = 4.14 μM for MCF7, 7.87 μM for C26), 3c (IC<sub>50</sub> = 4.98 μM for MCF7, 3.05 μM for C26), and 4c (IC<sub>50</sub> = 6.85 μM for MCF7, 1.71 μM for C26) exhibited potent cytotoxic activity with 4c (2,4-diCl, pyrrolidine) surpassing paclitaxel (IC<sub>50</sub> = 2.30 μM for C26), and 3c (3,4-diCl, pyrrolidine) rivali","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T09:24:25.979Z","creation":"2026-05-15T03:13:06.686Z"},"accession":"S-EPMC12560096","cross_references":{"pubmed":["41163837"],"doi":["10.1039/d5ra05705a"]}}