{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(10)"],"submitter":["Briggs EM"],"pubmed_abstract":["In this study, we present a re-envisioned design of an ion-sensitive field-effect transistor (ISFET)-based solid-state sensor for measuring pH and total alkalinity of seawater with electrolytically generated titrant. The original design requires either custom nanofabrication of ISFET wafers or back-end processing of fully fabricated ISFETs. Instead, we assembled all \"off-the-shelf\" parts to demonstrate the same measurement principle but with the titrant-generating electrode suspended orthogonal to the pH-sensing region of the ISFET rather than being physically deposited on the face of the chip. This offers many benefits including (1) avoiding disruption the pH functionality of the ISFET; (2) enabling the assessment of anode-gate distance sensitivity from a single ISFET; and (3) exploration"],"journal":["ACS sensors"],"pagination":["8045-8052"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12560134"],"repository":["biostudies-literature"],"pubmed_title":["Fine-Tuning an ISFET-Based Dual pH-Total Alkalinity Sensor for Operation in Seawater Using an Adjustable, Suspended Anode."],"pmcid":["PMC12560134"],"pubmed_authors":["Martz TR","Briggs EM"],"additional_accession":[]},"is_claimable":false,"name":"Fine-Tuning an ISFET-Based Dual pH-Total Alkalinity Sensor for Operation in Seawater Using an Adjustable, Suspended Anode.","description":"In this study, we present a re-envisioned design of an ion-sensitive field-effect transistor (ISFET)-based solid-state sensor for measuring pH and total alkalinity of seawater with electrolytically generated titrant. The original design requires either custom nanofabrication of ISFET wafers or back-end processing of fully fabricated ISFETs. Instead, we assembled all \"off-the-shelf\" parts to demonstrate the same measurement principle but with the titrant-generating electrode suspended orthogonal to the pH-sensing region of the ISFET rather than being physically deposited on the face of the chip. This offers many benefits including (1) avoiding disruption the pH functionality of the ISFET; (2) enabling the assessment of anode-gate distance sensitivity from a single ISFET; and (3) exploration","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-14T03:18:51.038Z","creation":"2026-05-14T03:12:27.774Z"},"accession":"S-EPMC12560134","cross_references":{"pubmed":["41016057"],"doi":["10.1021/acssensors.5c02765"]}}