{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(10)"],"submitter":["Gianibbi B"],"pubmed_abstract":["<b>Background/Objectives</b>: Malaria remains the most critical parasitic disease globally, responsible for over 600.000 deaths annually. In sub-Saharan Africa, co-infections of <i>Plasmodium falciparum</i> with other pathogens, particularly <i>Staphylococcus aureus</i>, are common in children with severe malaria. Therefore, the design of new compounds targeting both pathogens appears to be an urgent priority. <b>Methods</b>: A small series of hybrid compounds was designed and synthesized by linking the pharmacophore of the antimalarial drug chloroquine with the phenothiazine core. These compounds were tested in vitro against a panel of microbial strains and further analyzed through in silico simulations to predict their physical-chemical properties. <b>Results</b>: Compounds <b>4b</b> and"],"journal":["Antibiotics (Basel, Switzerland)"],"pagination":["991"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12561106"],"repository":["biostudies-literature"],"pubmed_title":["STOP Strategy to Inhibit &lt;i&gt;P. falciparum&lt;/i&gt; and &lt;i&gt;S. aureus&lt;/i&gt; Growth: Molecular Mechanism Studies on Purposely Designed Hybrids."],"pmcid":["PMC12561106"],"pubmed_authors":["Gentilomi GA","Bonvicini F","Gobbi S","Belluti F","Bisi A","Basilico N","Parapini S","Corina R","Gianibbi B","Spiga O"],"additional_accession":[]},"is_claimable":false,"name":"STOP Strategy to Inhibit &lt;i&gt;P. falciparum&lt;/i&gt; and &lt;i&gt;S. aureus&lt;/i&gt; Growth: Molecular Mechanism Studies on Purposely Designed Hybrids.","description":"<b>Background/Objectives</b>: Malaria remains the most critical parasitic disease globally, responsible for over 600.000 deaths annually. In sub-Saharan Africa, co-infections of <i>Plasmodium falciparum</i> with other pathogens, particularly <i>Staphylococcus aureus</i>, are common in children with severe malaria. Therefore, the design of new compounds targeting both pathogens appears to be an urgent priority. <b>Methods</b>: A small series of hybrid compounds was designed and synthesized by linking the pharmacophore of the antimalarial drug chloroquine with the phenothiazine core. These compounds were tested in vitro against a panel of microbial strains and further analyzed through in silico simulations to predict their physical-chemical properties. <b>Results</b>: Compounds <b>4b</b> and","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-15T03:18:24.856Z","creation":"2026-05-15T03:12:26.05Z"},"accession":"S-EPMC12561106","cross_references":{"pubmed":["41148683"],"doi":["10.3390/antibiotics14100991"]}}