{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(40)"],"submitter":["Han H"],"pubmed_abstract":["Hepatocellular carcinoma (HCC) is a common malignant tumor. However, the role of lactic acid-modified proteins in its pathogenesis is unclear. This study determines the distribution of a novel post-translational modification-protein lactylation-in HCC to identify potential targets and obtain mechanistic insights into this disease. Using high-throughput proteomics, lysine 312 lactylation (K312-lac) of the Set1/Ash2 histone methyltransferase complex subunit (ASH2L) is revealed as a candidate for further investigation. Subsequently, alanyl-tRNA synthetase 1 (AARS1) and histone deacetylase 1 (HDAC1) are shown to mediate lactylation modification of ASH2L. In vivo experiments demonstrate that ASH2L-K312-lac promotes HCC malignant progression and is positively correlated with tumor microvessel de"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pagination":["e09477"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12561209"],"repository":["biostudies-literature"],"pubmed_title":["ASH2L-K312-Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma."],"pmcid":["PMC12561209"],"pubmed_authors":["Ma L","Gu X","Xia S","Zhu H","Cheng X","Yin H","Wang S","Zhang Y","Han H","Liu C","Zhao D","Wang Y","Zhu R","Yuan Y"],"additional_accession":[]},"is_claimable":false,"name":"ASH2L-K312-Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma.","description":"Hepatocellular carcinoma (HCC) is a common malignant tumor. However, the role of lactic acid-modified proteins in its pathogenesis is unclear. This study determines the distribution of a novel post-translational modification-protein lactylation-in HCC to identify potential targets and obtain mechanistic insights into this disease. Using high-throughput proteomics, lysine 312 lactylation (K312-lac) of the Set1/Ash2 histone methyltransferase complex subunit (ASH2L) is revealed as a candidate for further investigation. Subsequently, alanyl-tRNA synthetase 1 (AARS1) and histone deacetylase 1 (HDAC1) are shown to mediate lactylation modification of ASH2L. In vivo experiments demonstrate that ASH2L-K312-lac promotes HCC malignant progression and is positively correlated with tumor microvessel de","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T09:29:51.618Z","creation":"2026-05-15T03:12:17.113Z"},"accession":"S-EPMC12561209","cross_references":{"pubmed":["40726441"],"doi":["10.1002/advs.202509477"]}}