{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(10)"],"submitter":["Giannotti L"],"pubmed_abstract":["<h4>Background</h4>Glioblastoma (GBM) is a highly aggressive tumor characterized by elevated plasticity and poor differentiation. Platelet-derived preparations such as Concentrated Growth Factors (CGF) are rich in bioactive molecules, but their effects on tumor biology remain underexplored.<h4>Methods</h4>U87MG glioblastoma cells were cultured with a conditioned medium obtained from CGF over 14 days (CGF-CM). We analyzed cell viability, morphology, DNA integrity, migration, proliferation, and expression of astrocytic markers.<h4>Results</h4>CGF-CM treatment induced early enhancement of cell viability, followed by decreased proliferation and reduced migration at later time points. Morphological analyses revealed astrocyte-like features. The expression of glial fibrillary acidic protein (GFA"],"journal":["Biology"],"pagination":["1461"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12561328"],"repository":["biostudies-literature"],"pubmed_title":["CGF-Conditioned Medium Modulates Astrocytic Differentiation and Invasiveness in U87MG Glioblastoma Cells."],"pmcid":["PMC12561328"],"pubmed_authors":["Demitri C","Damiano F","Palermo A","Spedicato F","De Sangro MA","Stanca E","Ferrante F","Siculella L","Giannotti L","Di Chiara Stanca B","Abbruzzese L"],"additional_accession":[]},"is_claimable":false,"name":"CGF-Conditioned Medium Modulates Astrocytic Differentiation and Invasiveness in U87MG Glioblastoma Cells.","description":"<h4>Background</h4>Glioblastoma (GBM) is a highly aggressive tumor characterized by elevated plasticity and poor differentiation. Platelet-derived preparations such as Concentrated Growth Factors (CGF) are rich in bioactive molecules, but their effects on tumor biology remain underexplored.<h4>Methods</h4>U87MG glioblastoma cells were cultured with a conditioned medium obtained from CGF over 14 days (CGF-CM). We analyzed cell viability, morphology, DNA integrity, migration, proliferation, and expression of astrocytic markers.<h4>Results</h4>CGF-CM treatment induced early enhancement of cell viability, followed by decreased proliferation and reduced migration at later time points. Morphological analyses revealed astrocyte-like features. The expression of glial fibrillary acidic protein (GFA","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-15T03:10:50.383Z","creation":"2026-05-15T03:07:50.424Z"},"accession":"S-EPMC12561328","cross_references":{"pubmed":["41154863"],"doi":["10.3390/biology14101461"]}}