biostudies-literatureJia STechnology and Innovation Commission of ShenzhenShenzhen Medical Research FundsSTI2030-Major ProjectsGuangdong Basic and Applied Basic Research FoundationBasic and Applied Basic Research Foundation of Guangdong ProvinceShenzhen Key Basic Research ProjectNational Natural Science Foundation of China (NSFC)CAS Key Laboratory of Brain Connectome and Manipulatione15311https://www.ebi.ac.uk/biostudies/studies/S-EPMC12561400biostudies-literatureUnknown12(40)The effects of nicotine on aging-related motor and cognitive decline remain controversial due to limited empirical evidence. Here, mice are permitted to orally consume nicotine over a 22-month period and observed attenuated motor decline without pathological alterations in major metabolism-related peripheral organs or immune system dysfunction. Multi-organ metabolomic profiling and network analysis of aged mice (24 months old) identified nicotine-responsive pathways related to glycolipid metabolism and energy homeostasis. Dynamic gut microbiota profiling via series expression miner-based longitudinal analysis reveals that nicotine consumption preserved microbiota composition and altered microbial-derived metabolites associated with the sphingolipid pathway, known to regulate age-related muAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice.PMC12561400JCYJ202001091156417622022ZD02071002019A1515110190D23010022019DP1730242023A151501174332371213ZDSYS20190902093601675Ren XZou JLu ZYu QSu MHuang KWang JWang LJing XWei PWang PWang RChen ZJia SJia YMo ZZou QSu WKang LFeng YZeng ZTu LHong FYang XKenny PJPan FZhong GYan CLiu XAfalseNicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice.The effects of nicotine on aging-related motor and cognitive decline remain controversial due to limited empirical evidence. Here, mice are permitted to orally consume nicotine over a 22-month period and observed attenuated motor decline without pathological alterations in major metabolism-related peripheral organs or immune system dysfunction. Multi-organ metabolomic profiling and network analysis of aged mice (24 months old) identified nicotine-responsive pathways related to glycolipid metabolism and energy homeostasis. Dynamic gut microbiota profiling via series expression miner-based longitudinal analysis reveals that nicotine consumption preserved microbiota composition and altered microbial-derived metabolites associated with the sphingolipid pathway, known to regulate age-related mu2025-01-01T00:00:00Z2025 Oct2026-06-05T07:42:34.812Z2026-05-14T03:12:07.147ZS-EPMC125614004071902010.1002/advs.202415311