{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhan C"],"funding":["University of Hong Kong Seed Fund for PI Research - Translational and Applied Research","National Natural Science Foundation of China Young Scientists Fund"],"pagination":["e06438"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12561402"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(40)"],"pubmed_abstract":["Diabetes exacerbates the development and progression of periodontitis through the aggravation of persistent inflammation and tissue destruction. While the impact of diabetes on peripheral sensory nerves is well-documented, little is known about the role of diabetic neuropathy in bone destruction in diabetes-associated periodontitis. Herein, a significant loss of periodontal nerves is observed in the diabetic state of db/db mice, with trigeminal ganglion neurons showing decreased autophagy. These mice exhibit decreased density of calcitonin gene-related peptide (CGRP)<sup>+</sup> nerves, correlating with the progression of diabetes and inflammatory state. Furthermore, diabetic mice with periodontitis show greater alveolar bone loss, which can be phenocopied by periodontal denervation. Importantly, CGRP receptor-related components are found to be expressed in periodontal endothelial cells. In both diabetic and denervated periodontium, the loss of CGRP signaling is associated with the reduction of type H vessel density and coupled osterix<sup>+</sup> osteoprogenitors. To elaborate further, an injectable reactive oxygen species-responsive poly(vinyl alcohol) (PVA)/tsPBA hydrogel is developed for sustained CGRP delivery. Notably, the CGRP-loaded hydrogels promote alveolar bone regeneration via inducing type H vessel formation in diabetic mice. The findings highlight that diabetes-induced sensory nerve damage may exacerbate periodontitis-induced bone loss, and CGRP@PVA/tsPBA hydrogels offer a promising therapeutic strategy for bone regeneration."],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["CGRP-Loaded ROS-Responsive Hydrogel Restores Neuro-Angiogenic Signaling to Promote Bone Regeneration in Diabetes-Associated Periodontitis."],"pmcid":["PMC12561402"],"funding_grant_id":["2403101930","2203100705","82401109"],"pubmed_authors":["Tsoi JKH","Zhan C","Dai Q","Ren J","Wang W","Lin Y","Jin L","Ye Z"],"additional_accession":[]},"is_claimable":false,"name":"CGRP-Loaded ROS-Responsive Hydrogel Restores Neuro-Angiogenic Signaling to Promote Bone Regeneration in Diabetes-Associated Periodontitis.","description":"Diabetes exacerbates the development and progression of periodontitis through the aggravation of persistent inflammation and tissue destruction. While the impact of diabetes on peripheral sensory nerves is well-documented, little is known about the role of diabetic neuropathy in bone destruction in diabetes-associated periodontitis. Herein, a significant loss of periodontal nerves is observed in the diabetic state of db/db mice, with trigeminal ganglion neurons showing decreased autophagy. These mice exhibit decreased density of calcitonin gene-related peptide (CGRP)<sup>+</sup> nerves, correlating with the progression of diabetes and inflammatory state. Furthermore, diabetic mice with periodontitis show greater alveolar bone loss, which can be phenocopied by periodontal denervation. Importantly, CGRP receptor-related components are found to be expressed in periodontal endothelial cells. In both diabetic and denervated periodontium, the loss of CGRP signaling is associated with the reduction of type H vessel density and coupled osterix<sup>+</sup> osteoprogenitors. To elaborate further, an injectable reactive oxygen species-responsive poly(vinyl alcohol) (PVA)/tsPBA hydrogel is developed for sustained CGRP delivery. Notably, the CGRP-loaded hydrogels promote alveolar bone regeneration via inducing type H vessel formation in diabetic mice. The findings highlight that diabetes-induced sensory nerve damage may exacerbate periodontitis-induced bone loss, and CGRP@PVA/tsPBA hydrogels offer a promising therapeutic strategy for bone regeneration.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T09:12:29.704Z","creation":"2026-05-15T03:12:23.572Z"},"accession":"S-EPMC12561402","cross_references":{"pubmed":["40755317"],"doi":["10.1002/advs.202506438"]}}