biostudies-literatureLing YShenzhen Science and Technology Innovation ProgramCollaborative Innovation Center of Suzhou Nano Science and TechnologyPriority Academic Program Development of Jiangsu Higher Education InstitutionsNational Natural Science Foundation of ChinaNational Key Research and Development Program of Chinae07189https://www.ebi.ac.uk/biostudies/studies/S-EPMC12561424biostudies-literatureUnknown12(40)Surface-Enhanced Raman Scattering (SERS) shows promise for monitoring health during space missions, particularly in assessing the effects of microgravity and radiation. However, traditional SERS sensors struggle with precise interfacial engineering, leading to a relatively poor assembly efficiency, and are unable to meet the practical needs of extreme spaceflight environments. To address this, it is designed and fabricated precision-arranged DNA origami plasmonic nanoantennas. By leveraging DNA origami's addressability, it is built a 3 × 4 antenna array with a controlled spacing of 21.76 nm, enhancing assembly efficiency fourfold compared to disordered systems. The ordered system enabled accurate detection of calcium ions, interleukin-6, and microRNA-214 in serum from mice exposed to microAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Precision-Arranged DNA Origami Plasmonic Nanoantennas for Multidimensional Smart-Warning of Weightlessness Induced Bone Loss.PMC1256142482192883SYW2024068523251062023YFB32082002022YFA110430022074101Li JLing YZhang JQin XSun WWang HXu HXie RLi YYue FYang YZhou GLi BWang YFan DfalsePrecision-Arranged DNA Origami Plasmonic Nanoantennas for Multidimensional Smart-Warning of Weightlessness Induced Bone Loss.Surface-Enhanced Raman Scattering (SERS) shows promise for monitoring health during space missions, particularly in assessing the effects of microgravity and radiation. However, traditional SERS sensors struggle with precise interfacial engineering, leading to a relatively poor assembly efficiency, and are unable to meet the practical needs of extreme spaceflight environments. To address this, it is designed and fabricated precision-arranged DNA origami plasmonic nanoantennas. By leveraging DNA origami's addressability, it is built a 3 × 4 antenna array with a controlled spacing of 21.76 nm, enhancing assembly efficiency fourfold compared to disordered systems. The ordered system enabled accurate detection of calcium ions, interleukin-6, and microRNA-214 in serum from mice exposed to micro2025-01-01T00:00:00Z2025 Oct2026-06-05T08:47:22.173Z2026-05-14T03:12:48.318ZS-EPMC125614244078805310.1002/advs.202507189