{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li C"],"funding":["Deutsche Forschungsgemeinschaft","European Research Council","NIDDK NIH HHS","Chinese Scholarship Council. Deutsche Forschungsgemeinschaft","Prof. Martha Merrow and Dr. Francesca Sartor of the LMU generously provided access to and expertise regarding the Nikon Eclipse Ti2 microscope system","National Institutes of Health","NIH HHS"],"pagination":["e06707"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12561471"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(40)"],"pubmed_abstract":["RNA-binding proteins regulate post-transcriptional gene translation, but the macrophage-specific role of Zc3h12c remains poorly characterized. Here, the role of Zc3h12c in macrophages is characterized using Tnfrsf11a<sup>Cre</sup>-Zc3h12c<sup>flox/flox</sup> mice. Both Tnfrsf11a and Zc3h12c are highly expressed in the kidney tissue from patients with chronic kidney disease and showed a positive association with an interstitial fibrosis score. Single cell RNA sequencing demonstrated abundant Tnfrsf11a expression in murine kidney macrophages and a correlation with the induction of chemokines, macrophage phagocytosis, and activation upon kidney injury. In various kidney injury models, Tnfrsf11a<sup>Cre</sup>-Zc3h12c<sup>flox/flox</sup> mice suffered from more injury and inflammation in the ki"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre-mRNA."],"pmcid":["PMC12561471"],"funding_grant_id":["R01DK076077","INST 86/1851-1 FUGG","R01 DK087635","SFB TRR332","R01 DK076077","R01 DK105821","R01DK105821","R01DK087635","648274","GZ:INST 86/1851-1 FUGG","AN372/30-1","TRR332"],"pubmed_authors":["Li C","Zhu Z","Lech M","Susztak K","Schulz C","Zhang N","Kusunoki Y","Marschner JA","Watanabe-Kusunoki K","Zhao Z","Deng H","Li X","Anders HJ","Steiger S","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre-mRNA.","description":"RNA-binding proteins regulate post-transcriptional gene translation, but the macrophage-specific role of Zc3h12c remains poorly characterized. Here, the role of Zc3h12c in macrophages is characterized using Tnfrsf11a<sup>Cre</sup>-Zc3h12c<sup>flox/flox</sup> mice. Both Tnfrsf11a and Zc3h12c are highly expressed in the kidney tissue from patients with chronic kidney disease and showed a positive association with an interstitial fibrosis score. Single cell RNA sequencing demonstrated abundant Tnfrsf11a expression in murine kidney macrophages and a correlation with the induction of chemokines, macrophage phagocytosis, and activation upon kidney injury. In various kidney injury models, Tnfrsf11a<sup>Cre</sup>-Zc3h12c<sup>flox/flox</sup> mice suffered from more injury and inflammation in the ki","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-05T08:58:16.455Z","creation":"2026-05-15T03:07:54.636Z"},"accession":"S-EPMC12561471","cross_references":{"pubmed":["40834429"],"doi":["10.1002/advs.202506707"]}}