{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tomasini N"],"funding":["Agencia Nacional de Promoción Científica y Tecnológica"],"pagination":["1394"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12562267"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(10)"],"pubmed_abstract":["The mitochondrial DNA of trypanosomatid parasites consists of thousands of catenated minicircles and dozens of maxicircles that form a complex network structure, the kinetoplast (kDNA). Although kDNA replication and segregation during mitotic division are well studied, its inheritance during genetic exchange events remains unclear. In <i>Trypanosoma brucei</i>, hybrids inherit minicircles biparentally but retain maxicircles from a single parent. Although biparental inheritance of minicircles has been described in natural <i>Trypanosoma cruzi</i> hybrids, this process has not been explored in laboratory-generated hybrids of this parasite. In the present study, we analyzed kDNA inheritance in <i>T. cruzi</i> experimental hybrids using a comprehensive minicircle hypervariable region (mHVR) da"],"journal":["Biology"],"pubmed_title":["Biparental Inheritance and Instability of kDNA in Experimental Hybrids of &lt;i&gt;Trypanosoma cruzi&lt;/i&gt;: A Proposal for a Mechanism."],"pmcid":["PMC12562267"],"funding_grant_id":["PICT2019-02855"],"pubmed_authors":["Diosque P","Tomasini N","Rusman F","Lewis MD","Aguirre JJ","Hodi S","Matos GM","Diaz AG","Andersson B","Ponce T","Floridia-Yapur N"],"additional_accession":[]},"is_claimable":false,"name":"Biparental Inheritance and Instability of kDNA in Experimental Hybrids of &lt;i&gt;Trypanosoma cruzi&lt;/i&gt;: A Proposal for a Mechanism.","description":"The mitochondrial DNA of trypanosomatid parasites consists of thousands of catenated minicircles and dozens of maxicircles that form a complex network structure, the kinetoplast (kDNA). Although kDNA replication and segregation during mitotic division are well studied, its inheritance during genetic exchange events remains unclear. In <i>Trypanosoma brucei</i>, hybrids inherit minicircles biparentally but retain maxicircles from a single parent. Although biparental inheritance of minicircles has been described in natural <i>Trypanosoma cruzi</i> hybrids, this process has not been explored in laboratory-generated hybrids of this parasite. In the present study, we analyzed kDNA inheritance in <i>T. cruzi</i> experimental hybrids using a comprehensive minicircle hypervariable region (mHVR) da","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-15T03:18:00.646Z","creation":"2026-05-15T03:12:19.965Z"},"accession":"S-EPMC12562267","cross_references":{"pubmed":["41154795"],"doi":["10.3390/biology14101394"]}}