{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Le Z"],"funding":["the National Natural Science Foundation of China","International Science and Technology Cooperation Key Special Project of the National Key Re-search and Development Program"],"pagination":["1176"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12562280"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(10)"],"pubmed_abstract":["<b>Background:</b> The Tibetan Plateau, which is known for its high elevation and low oxygen levels, presents a challenging environment for its inhabitants. To adapt to these hypoxic conditions, species of <i>Schizothoracine</i>, a subfamily of <i>Cyprinidae</i>, have developed unique physiological mechanisms and functions. Transforming growth factor-β (TGF-β) is a multifunctional cytokine involved in the regulation of cell growth, differentiation, apoptosis, and the cellular immune response. However, its specific role in adaptation to hypoxia remains poorly understood. <b>Methods:</b> In this study, we aimed to characterize the TGF-β1 gene in <i>Gymnocypris dobula</i> (<i>Gd</i>) and <i>Schizothorax prenanti</i> (<i>Sp</i>) and to test whether TGF-β1 contributes to hypoxia adaptation in p"],"journal":["Genes"],"pubmed_title":["Analysis of the TGF-β1 of a Tibetan Plateau &lt;i&gt;Schizothoracine&lt;/i&gt; Fish (&lt;i&gt;Gymnocypris dobula&lt;/i&gt;) Revealed Enhanced Cytoprotection in Hypoxic Environments."],"pmcid":["PMC12562280"],"funding_grant_id":["31702312","2023YFE0104500"],"pubmed_authors":["Liu Y","Wang C","Le Z","Xu Q","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of the TGF-β1 of a Tibetan Plateau &lt;i&gt;Schizothoracine&lt;/i&gt; Fish (&lt;i&gt;Gymnocypris dobula&lt;/i&gt;) Revealed Enhanced Cytoprotection in Hypoxic Environments.","description":"<b>Background:</b> The Tibetan Plateau, which is known for its high elevation and low oxygen levels, presents a challenging environment for its inhabitants. To adapt to these hypoxic conditions, species of <i>Schizothoracine</i>, a subfamily of <i>Cyprinidae</i>, have developed unique physiological mechanisms and functions. Transforming growth factor-β (TGF-β) is a multifunctional cytokine involved in the regulation of cell growth, differentiation, apoptosis, and the cellular immune response. However, its specific role in adaptation to hypoxia remains poorly understood. <b>Methods:</b> In this study, we aimed to characterize the TGF-β1 gene in <i>Gymnocypris dobula</i> (<i>Gd</i>) and <i>Schizothorax prenanti</i> (<i>Sp</i>) and to test whether TGF-β1 contributes to hypoxia adaptation in p","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-15T03:24:44.368Z","creation":"2026-05-15T03:08:39.747Z"},"accession":"S-EPMC12562280","cross_references":{"pubmed":["41153393"],"doi":["10.3390/genes16101176"]}}