{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu Q"],"funding":["National Natural Science Foundation of China"],"pagination":["809"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12562522"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["47(10)"],"pubmed_abstract":["Acute lung injury (ALI) is a severe pulmonary disorder characterized by the disruption of the alveolar-capillary barrier, leading to impaired oxygenation and pulmonary edema. Current pharmacological interventions primarily involve the use of steroid drugs, oxygen radical scavengers, and bronchodilators. However, the therapeutic efficacy of these interventions remains inconsistent. Canthin-6-ones, a class of tryptophan-derived alkaloids, exhibit anti-inflammatory, antioxidant, and immunomodulatory properties. In this study, we synthesized a novel Canthin-6-one derivative, namely HCX3, and evaluated its potential beneficial effects and underlying mechanisms on ALI. Prior to the experimental study, network pharmacology analysis revealed that HCX3 may exert anti-inflammatory effects in the con"],"journal":["Current issues in molecular biology"],"pubmed_title":["HCX3 Mitigates LPS-Induced Inflammatory Responses in Macrophages by Suppressing the Activation of the NF-κB Signaling Pathway."],"pmcid":["PMC12562522"],"funding_grant_id":["32270919"],"pubmed_authors":["Wu L","Ling Y","Zhang J","Wu Q","Shi J","Li L","Mao L"],"additional_accession":[]},"is_claimable":false,"name":"HCX3 Mitigates LPS-Induced Inflammatory Responses in Macrophages by Suppressing the Activation of the NF-κB Signaling Pathway.","description":"Acute lung injury (ALI) is a severe pulmonary disorder characterized by the disruption of the alveolar-capillary barrier, leading to impaired oxygenation and pulmonary edema. Current pharmacological interventions primarily involve the use of steroid drugs, oxygen radical scavengers, and bronchodilators. However, the therapeutic efficacy of these interventions remains inconsistent. Canthin-6-ones, a class of tryptophan-derived alkaloids, exhibit anti-inflammatory, antioxidant, and immunomodulatory properties. In this study, we synthesized a novel Canthin-6-one derivative, namely HCX3, and evaluated its potential beneficial effects and underlying mechanisms on ALI. Prior to the experimental study, network pharmacology analysis revealed that HCX3 may exert anti-inflammatory effects in the con","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-15T03:24:59.392Z","creation":"2026-05-15T03:08:42.157Z"},"accession":"S-EPMC12562522","cross_references":{"pubmed":["41150757"],"doi":["10.3390/cimb47100809"]}}