{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen L"],"funding":["Yan Wu","Yan WU"],"pagination":["1630"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12562530"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(20)"],"pubmed_abstract":["In poultry production, the laying rate is a critical economic trait, as high egg production significantly enhances profitability. Mitogen-activated protein kinase-activated protein kinase 3 (<i>MK3</i>) is a member of the mitogen-activated protein kinase (MAPK) family, which plays an important role in follicular development. Our previous RNA-seq analysis revealed that <i>MK3</i> expression was significantly altered in the ovaries of laying hens exposed to normal versus light-deprivation conditions. Based on previous RNA-seq analysis of chicken ovaries, this study focused on the <i>MK3</i> gene to explore its role in regulating apoptosis of follicular granulosa cells in laying hens. The results demonstrated that <i>MK3</i> overexpression induced granulosa cell apoptosis by modulating the ex"],"journal":["Cells"],"pubmed_title":["&lt;i&gt;MK3&lt;/i&gt; Gene Upregulates Granulosa Cell Apoptosis Through the TNF/P38 MAPK Pathway in Chicken."],"pmcid":["PMC12562530"],"funding_grant_id":["China Agriculture Research System of MOF and MARA (CARS-40, CARS-41)","National Key Research and Development Program of China (2022YFD1300100)","National Natural Science Foundation of China (32202665)","Supports High Quality Development of Seed Industry Fund Project of Hubei Province (HBZY2023B007),"],"pubmed_authors":["Liu J","Zhang Y","Pi J","Chen L","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;MK3&lt;/i&gt; Gene Upregulates Granulosa Cell Apoptosis Through the TNF/P38 MAPK Pathway in Chicken.","description":"In poultry production, the laying rate is a critical economic trait, as high egg production significantly enhances profitability. Mitogen-activated protein kinase-activated protein kinase 3 (<i>MK3</i>) is a member of the mitogen-activated protein kinase (MAPK) family, which plays an important role in follicular development. Our previous RNA-seq analysis revealed that <i>MK3</i> expression was significantly altered in the ovaries of laying hens exposed to normal versus light-deprivation conditions. Based on previous RNA-seq analysis of chicken ovaries, this study focused on the <i>MK3</i> gene to explore its role in regulating apoptosis of follicular granulosa cells in laying hens. The results demonstrated that <i>MK3</i> overexpression induced granulosa cell apoptosis by modulating the ex","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-14T03:21:03.883Z","creation":"2026-05-14T03:12:48.185Z"},"accession":"S-EPMC12562530","cross_references":{"pubmed":["41148845"],"doi":["10.3390/cells14201630"]}}