biostudies-literatureUnknown16(10)Campos MAF<h4>Background/objectives</h4>Morphological defects such as limb malformations, cranial asymmetries, loin deviations, jaw misalignments, and navel irregularities are associated with early culling and reduced productivity in beef cattle. In <i>Bos taurus indicus</i> such as Nellore, the genetic basis of these traits remains poorly characterized. This study aimed to investigate the genetic architecture of six morphological defects in Nellore cattle, namely feet and legs malformation, chamfer asymmetry, fallen hump, loin deviation, jaw misalignment, and navel irregularities, via a genome-wide association study (GWAS) approach tailored for binary traits.<h4>Methods</h4>Depending on the trait, the number of genotyped animals analyzed ranged from 3369 to 23,206, using 385,079 SNPs (after qualityGenes1204https://www.ebi.ac.uk/biostudies/studies/S-EPMC12562650biostudies-literatureGenome-Wide Association Study of Morphological Defects in Nellore Cattle Using a Binary Trait Framework.PMC12562650Camargo GMFCosta RBCampos MAFMulim HAOliveira EDSFonseca PASRojas de Oliveira HfalseGenome-Wide Association Study of Morphological Defects in Nellore Cattle Using a Binary Trait Framework.<h4>Background/objectives</h4>Morphological defects such as limb malformations, cranial asymmetries, loin deviations, jaw misalignments, and navel irregularities are associated with early culling and reduced productivity in beef cattle. In <i>Bos taurus indicus</i> such as Nellore, the genetic basis of these traits remains poorly characterized. This study aimed to investigate the genetic architecture of six morphological defects in Nellore cattle, namely feet and legs malformation, chamfer asymmetry, fallen hump, loin deviation, jaw misalignment, and navel irregularities, via a genome-wide association study (GWAS) approach tailored for binary traits.<h4>Methods</h4>Depending on the trait, the number of genotyped animals analyzed ranged from 3369 to 23,206, using 385,079 SNPs (after quality2025-01-01T00:00:00Z2025 Oct2026-05-15T03:22:31.095Z2026-05-15T03:12:27.302ZS-EPMC125626504115342010.3390/genes16101204