{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Connell JR"],"funding":["Department of Defence Innovation Hub"],"pagination":["1211"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12562835"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(10)"],"pubmed_abstract":["<h4>Background/objectives</h4>High differentiation rates provided by Y-chromosomal short tandem repeats (Y-STRs) are highly advantageous in most forensic and genealogical casework, as they enhance the ability to exclude close or moderately related individuals, refine an individual's position within a pedigree, and uncover the population substructure in otherwise homogeneous groups. However, the impact for historical remains identification casework is underexplored.<h4>Methods</h4>We present a pedigree analysis of 366 males from 183 pedigrees, separated by 4 to 16 meioses at 27 Y-STR loci, from the Yfiler Plus kit. The differentiation rate for a given degree of separation was defined as the proportion of pairs at that specific number of meioses showing at least one allelic difference, relat"],"journal":["Genes"],"pubmed_title":["Pedigree-Based Estimation of Y-STR Mutation and Male Differentiation Rates: Application to Historical Remains Identification."],"pmcid":["PMC12562835"],"funding_grant_id":["P19-209484"],"pubmed_authors":["Zielke T","Armstrong L","Griffiths LR","Mitchell N","White T","Connell JR"],"additional_accession":[]},"is_claimable":false,"name":"Pedigree-Based Estimation of Y-STR Mutation and Male Differentiation Rates: Application to Historical Remains Identification.","description":"<h4>Background/objectives</h4>High differentiation rates provided by Y-chromosomal short tandem repeats (Y-STRs) are highly advantageous in most forensic and genealogical casework, as they enhance the ability to exclude close or moderately related individuals, refine an individual's position within a pedigree, and uncover the population substructure in otherwise homogeneous groups. However, the impact for historical remains identification casework is underexplored.<h4>Methods</h4>We present a pedigree analysis of 366 males from 183 pedigrees, separated by 4 to 16 meioses at 27 Y-STR loci, from the Yfiler Plus kit. The differentiation rate for a given degree of separation was defined as the proportion of pairs at that specific number of meioses showing at least one allelic difference, relat","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-14T03:20:51.929Z","creation":"2026-05-14T03:12:49.144Z"},"accession":"S-EPMC12562835","cross_references":{"pubmed":["41153428"],"doi":["10.3390/genes16101211"]}}