{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guo SP"],"funding":["Qing-Lan Projects of Jiangsu Province, China","Postgraduate Research & Practice Innovation Program of Jiangsu Province","National Natural Science Foundation of China"],"pagination":["1465"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12562854"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(10)"],"pubmed_abstract":["In the present study, seven previously undescribed resin glycosides, designated cusponins I-VII (<b>1</b>-<b>7</b>), together with one known analog (<b>8</b>), were isolated from the seeds of <i>Cuscuta japonica</i>, a traditional medicine used in China. Structural elucidation revealed them to be glycosidic acid methyl esters, generated through on-column methyl esterification of naturally occurring resin glycosides catalyzed by NH<sub>2</sub>-functionalized silica gel. All isolates were characterized as either pentasaccharides or tetrasaccharides, incorporating D-glucose, L-rhamnose, or D-fucose units as the sugar residues. Notably, compounds <b>1</b> and <b>3</b>-<b>7</b> contained the uncommon aglycone, 11<i>S</i>-hydroxypentadecanoic acid. Bioactivity assessments demonstrated that compo"],"journal":["Biomolecules"],"pubmed_title":["Resin Glycosides with &lt;i&gt;α&lt;/i&gt;-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitory Activities from the Seeds of &lt;i&gt;Cuscuta japonica&lt;/i&gt;."],"pmcid":["PMC12562854"],"funding_grant_id":["32370419","KYCX25_3843"],"pubmed_authors":["Wang WL","He Y","Guo J","Chen GT","Gu JP","Guo SP","Yang M","Fan BY","Qi TZ","Lan X","Wang XY"],"additional_accession":[]},"is_claimable":false,"name":"Resin Glycosides with &lt;i&gt;α&lt;/i&gt;-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitory Activities from the Seeds of &lt;i&gt;Cuscuta japonica&lt;/i&gt;.","description":"In the present study, seven previously undescribed resin glycosides, designated cusponins I-VII (<b>1</b>-<b>7</b>), together with one known analog (<b>8</b>), were isolated from the seeds of <i>Cuscuta japonica</i>, a traditional medicine used in China. Structural elucidation revealed them to be glycosidic acid methyl esters, generated through on-column methyl esterification of naturally occurring resin glycosides catalyzed by NH<sub>2</sub>-functionalized silica gel. All isolates were characterized as either pentasaccharides or tetrasaccharides, incorporating D-glucose, L-rhamnose, or D-fucose units as the sugar residues. Notably, compounds <b>1</b> and <b>3</b>-<b>7</b> contained the uncommon aglycone, 11<i>S</i>-hydroxypentadecanoic acid. Bioactivity assessments demonstrated that compo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-15T03:18:20.357Z","creation":"2026-05-15T03:07:53.398Z"},"accession":"S-EPMC12562854","cross_references":{"pubmed":["41154693"],"doi":["10.3390/biom15101465"]}}