biostudies-literatureGuo SPQing-Lan Projects of Jiangsu Province, ChinaPostgraduate Research & Practice Innovation Program of Jiangsu ProvinceNational Natural Science Foundation of China1465https://www.ebi.ac.uk/biostudies/studies/S-EPMC12562854biostudies-literatureUnknown15(10)In the present study, seven previously undescribed resin glycosides, designated cusponins I-VII (1-7), together with one known analog (8), were isolated from the seeds of Cuscuta japonica, a traditional medicine used in China. Structural elucidation revealed them to be glycosidic acid methyl esters, generated through on-column methyl esterification of naturally occurring resin glycosides catalyzed by NH2-functionalized silica gel. All isolates were characterized as either pentasaccharides or tetrasaccharides, incorporating D-glucose, L-rhamnose, or D-fucose units as the sugar residues. Notably, compounds 1 and 3-7 contained the uncommon aglycone, 11S-hydroxypentadecanoic acid. Bioactivity assessments demonstrated that compoBiomoleculesResin Glycosides with α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitory Activities from the Seeds of Cuscuta japonica.PMC1256285432370419KYCX25_3843Wang WLHe YGuo JChen GTGu JPGuo SPYang MFan BYQi TZLan XWang XYfalseResin Glycosides with α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitory Activities from the Seeds of Cuscuta japonica.In the present study, seven previously undescribed resin glycosides, designated cusponins I-VII (1-7), together with one known analog (8), were isolated from the seeds of Cuscuta japonica, a traditional medicine used in China. Structural elucidation revealed them to be glycosidic acid methyl esters, generated through on-column methyl esterification of naturally occurring resin glycosides catalyzed by NH2-functionalized silica gel. All isolates were characterized as either pentasaccharides or tetrasaccharides, incorporating D-glucose, L-rhamnose, or D-fucose units as the sugar residues. Notably, compounds 1 and 3-7 contained the uncommon aglycone, 11S-hydroxypentadecanoic acid. Bioactivity assessments demonstrated that compo2025-01-01T00:00:00Z2025 Oct2026-05-15T03:18:20.357Z2026-05-15T03:07:53.398ZS-EPMC125628544115469310.3390/biom15101465