{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(20)"],"submitter":["Feng C"],"pubmed_abstract":["Alopecia is a highly prevalent hair loss disorder characterized by an abnormality in hair cycling. Induction of autophagy and secretion of growth factors by adipocyte precursors are sufficient to activate quiescent hair follicles, yet therapies targeting these processes remain limited. Here, we identify rebamipide-a drug originally intended for gastric ulcer treatment-as a promising candidate for hair regeneration by modulating dermal adipocyte metabolism. Topical rebamipide treatment induces autophagy and adipose triglyceride lipase (ATGL)-mediated lipolysis in dermal adipocytes. Using primary culture systems, we demonstrate that rebamipide-driven lipolysis triggers adipocyte dedifferentiation, activating hair follicle stem cells (HFSCs) via elevated platelet-derived growth factor (PDGF) "],"journal":["International journal of molecular sciences"],"pagination":["10132"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12562944"],"repository":["biostudies-literature"],"pubmed_title":["Rebamipide Induces Hair Regeneration Through EP4-Driven Lipid Metabolism Remodeling."],"pmcid":["PMC12562944"],"pubmed_authors":["Wu L","Gu X","Diao W","Dong H","Gao Y","Xu D","Jiang D","Li R","Zhou Y","Feng C"],"additional_accession":[]},"is_claimable":false,"name":"Rebamipide Induces Hair Regeneration Through EP4-Driven Lipid Metabolism Remodeling.","description":"Alopecia is a highly prevalent hair loss disorder characterized by an abnormality in hair cycling. Induction of autophagy and secretion of growth factors by adipocyte precursors are sufficient to activate quiescent hair follicles, yet therapies targeting these processes remain limited. Here, we identify rebamipide-a drug originally intended for gastric ulcer treatment-as a promising candidate for hair regeneration by modulating dermal adipocyte metabolism. Topical rebamipide treatment induces autophagy and adipose triglyceride lipase (ATGL)-mediated lipolysis in dermal adipocytes. Using primary culture systems, we demonstrate that rebamipide-driven lipolysis triggers adipocyte dedifferentiation, activating hair follicle stem cells (HFSCs) via elevated platelet-derived growth factor (PDGF) ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-15T03:13:51.498Z","creation":"2026-05-15T03:08:07.736Z"},"accession":"S-EPMC12562944","cross_references":{"pubmed":["41155424"],"doi":["10.3390/ijms262010132"]}}