{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sykora M"],"funding":["VEGA grant","Ministry of Health of the Czech Republic within the project for the development of research or-ganization","project National Institute for Research of Metabolic and Cardiovascular Diseases","Slovak Research and Development Agency under Contract no.","European Regional Development Fund"],"pagination":["1457"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12562952"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(10)"],"pubmed_abstract":["Pressure overload in non-treated or resistant hypertension (HTN) increases the risk of heart failure (HF) as well as the occurrence of fatal ventricular arrhythmias and stroke-provoking atrial fibrillation (AF), while perturbed connexin-43 (Cx43) and Cx40 might be involved. In addition, kidney dysfunction may facilitate hemodynamic volume overload and congestive HF. We investigated the impact of volume overload on Cx43 and Cx40 in right and left heart atria of hypertensive pressure overloaded Ren-2 transgenic (TGR) strain and normotensive Hannover Sprague Dawley (HSD) rats, as well as the efficacy of renin-angiotensin blockade with trandolapril and losartan. Key novel findings revealed lower levels of Cx43 and Cx40 proteins in left as well as right heart atria in pressure overloaded hypert"],"journal":["Biomolecules"],"pubmed_title":["Trandolapril Attenuates Pro-Arrhythmic Downregulation of Cx43 and Cx40 in Atria of Volume Overloaded Hypertensive and Normotensive Rats."],"pmcid":["PMC12562952"],"funding_grant_id":["ITMS2014+: 313011AVG3","APVV-21-0410 and VV-MVP-24-0278","2/0006/23","[Grant Number 00023001 (IKEM)","(Program EXCELES, Project No. LX22NPO5104)- Funded by the European Union- Next Gene-ration EU"],"pubmed_authors":["Tribulova N","Ondrejak Andelova K","Szeiffova Bacova B","Mrvova A","Sykora M"],"additional_accession":[]},"is_claimable":false,"name":"Trandolapril Attenuates Pro-Arrhythmic Downregulation of Cx43 and Cx40 in Atria of Volume Overloaded Hypertensive and Normotensive Rats.","description":"Pressure overload in non-treated or resistant hypertension (HTN) increases the risk of heart failure (HF) as well as the occurrence of fatal ventricular arrhythmias and stroke-provoking atrial fibrillation (AF), while perturbed connexin-43 (Cx43) and Cx40 might be involved. In addition, kidney dysfunction may facilitate hemodynamic volume overload and congestive HF. We investigated the impact of volume overload on Cx43 and Cx40 in right and left heart atria of hypertensive pressure overloaded Ren-2 transgenic (TGR) strain and normotensive Hannover Sprague Dawley (HSD) rats, as well as the efficacy of renin-angiotensin blockade with trandolapril and losartan. Key novel findings revealed lower levels of Cx43 and Cx40 proteins in left as well as right heart atria in pressure overloaded hypert","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-14T03:12:13.115Z","creation":"2026-05-14T03:08:44.806Z"},"accession":"S-EPMC12562952","cross_references":{"pubmed":["41154686"],"doi":["10.3390/biom15101457"]}}