{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(10)"],"submitter":["Braila AD"],"pubmed_abstract":["<b>Background:</b> Endometrial proliferative lesions are common in the menopausal transition and carry a measurable risk of carcinoma. Early risk stratification may guide evaluation and follow-up. <b>Methods:</b> We performed a single-center retrospective study of 315 women aged 45-55 years (May 2021-May 2024) at a private clinic in Bucharest. Lesions were classified per WHO 2014 as hyperplasia without atypia, atypical hyperplasia/endometrial intraepithelial neoplasia (AH/EIN), or adenocarcinoma; \"advanced pathology\" was defined as AH/EIN or adenocarcinoma. Clinical comorbidities and transvaginal ultrasound endometrial thickness were recorded. Associations were tested with χ<sup>2</sup>; odds were estimated with multivariable logistic regression (adjusted ORs), with a modified Poisson sens"],"journal":["Clinics and practice"],"pagination":["177"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12563367"],"repository":["biostudies-literature"],"pubmed_title":["Clinical and Histopathological Correlates of Endometrial Proliferative Lesions in Perimenopausal Women: A Retrospective Study with Internal Validation of a Risk Model."],"pmcid":["PMC12563367"],"pubmed_authors":["Burcea A","Poalelungi CV","Braila AD","Damian CM","Albu CC","Cadar E","Tudor V","Bogdan-Andreescu CF","Banateanu AM"],"additional_accession":[]},"is_claimable":false,"name":"Clinical and Histopathological Correlates of Endometrial Proliferative Lesions in Perimenopausal Women: A Retrospective Study with Internal Validation of a Risk Model.","description":"<b>Background:</b> Endometrial proliferative lesions are common in the menopausal transition and carry a measurable risk of carcinoma. Early risk stratification may guide evaluation and follow-up. <b>Methods:</b> We performed a single-center retrospective study of 315 women aged 45-55 years (May 2021-May 2024) at a private clinic in Bucharest. Lesions were classified per WHO 2014 as hyperplasia without atypia, atypical hyperplasia/endometrial intraepithelial neoplasia (AH/EIN), or adenocarcinoma; \"advanced pathology\" was defined as AH/EIN or adenocarcinoma. Clinical comorbidities and transvaginal ultrasound endometrial thickness were recorded. Associations were tested with χ<sup>2</sup>; odds were estimated with multivariable logistic regression (adjusted ORs), with a modified Poisson sens","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-15T03:19:53.602Z","creation":"2026-05-15T03:12:14.849Z"},"accession":"S-EPMC12563367","cross_references":{"pubmed":["41148775"],"doi":["10.3390/clinpract15100177"]}}