biostudies-literatureUnknown15(10)Braila AD<b>Background:</b> Endometrial proliferative lesions are common in the menopausal transition and carry a measurable risk of carcinoma. Early risk stratification may guide evaluation and follow-up. <b>Methods:</b> We performed a single-center retrospective study of 315 women aged 45-55 years (May 2021-May 2024) at a private clinic in Bucharest. Lesions were classified per WHO 2014 as hyperplasia without atypia, atypical hyperplasia/endometrial intraepithelial neoplasia (AH/EIN), or adenocarcinoma; "advanced pathology" was defined as AH/EIN or adenocarcinoma. Clinical comorbidities and transvaginal ultrasound endometrial thickness were recorded. Associations were tested with χ²; odds were estimated with multivariable logistic regression (adjusted ORs), with a modified Poisson sensClinics and practice177https://www.ebi.ac.uk/biostudies/studies/S-EPMC12563367biostudies-literatureClinical and Histopathological Correlates of Endometrial Proliferative Lesions in Perimenopausal Women: A Retrospective Study with Internal Validation of a Risk Model.PMC12563367Burcea APoalelungi CVBraila ADDamian CMAlbu CCCadar ETudor VBogdan-Andreescu CFBanateanu AMfalseClinical and Histopathological Correlates of Endometrial Proliferative Lesions in Perimenopausal Women: A Retrospective Study with Internal Validation of a Risk Model.<b>Background:</b> Endometrial proliferative lesions are common in the menopausal transition and carry a measurable risk of carcinoma. Early risk stratification may guide evaluation and follow-up. <b>Methods:</b> We performed a single-center retrospective study of 315 women aged 45-55 years (May 2021-May 2024) at a private clinic in Bucharest. Lesions were classified per WHO 2014 as hyperplasia without atypia, atypical hyperplasia/endometrial intraepithelial neoplasia (AH/EIN), or adenocarcinoma; "advanced pathology" was defined as AH/EIN or adenocarcinoma. Clinical comorbidities and transvaginal ultrasound endometrial thickness were recorded. Associations were tested with χ²; odds were estimated with multivariable logistic regression (adjusted ORs), with a modified Poisson sens2025-01-01T00:00:00Z2025 Sep2026-05-15T03:19:53.602Z2026-05-15T03:12:14.849ZS-EPMC125633674114877510.3390/clinpract15100177