{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maejima Y"],"funding":["Japan Science and Technology Agency","Japan Society for the Promotion of Science"],"pagination":["390"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12565729"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(10)"],"pubmed_abstract":["The global increase in life expectancy underscores the need to promote healthy aging, particularly by addressing age-related leaky gut syndrome, which contributes to systemic inflammation and chronic disease. This study focused on the sustainable production and functional development of <i>Ulva meridionalis</i>, a fast-growing seaweed, to improve gut health and mitigate the effects of aging. Using land-based aquaculture, a scalable cultivation system for <i>U. meridionalis</i> was established, and its polysaccharide, ulvan, was extracted. Ion exchange treatment enhanced the functionality of ulvan to produce ulvan-Na, which contains high levels of Na<sup>+</sup> and conveys superior anti-aging properties. Ulvan-Na restored intestinal barrier integrity in aged mice by reducing serum LPS leve"],"journal":["Marine drugs"],"pubmed_title":["Ulvan-Na, an Ulvan Subjected to Na&lt;sup&gt;+&lt;/sup&gt; Cation Exchange, Improves Intestinal Barrier Function in Age-Related Leaky Gut."],"pmcid":["PMC12565729"],"funding_grant_id":["JPMJSF23BD","16K18874"],"pubmed_authors":["Maejima Y","Onda A","Hiraoka M","Namba T","Morioka Y","Sato Y"],"additional_accession":[]},"is_claimable":false,"name":"Ulvan-Na, an Ulvan Subjected to Na&lt;sup&gt;+&lt;/sup&gt; Cation Exchange, Improves Intestinal Barrier Function in Age-Related Leaky Gut.","description":"The global increase in life expectancy underscores the need to promote healthy aging, particularly by addressing age-related leaky gut syndrome, which contributes to systemic inflammation and chronic disease. This study focused on the sustainable production and functional development of <i>Ulva meridionalis</i>, a fast-growing seaweed, to improve gut health and mitigate the effects of aging. Using land-based aquaculture, a scalable cultivation system for <i>U. meridionalis</i> was established, and its polysaccharide, ulvan, was extracted. Ion exchange treatment enhanced the functionality of ulvan to produce ulvan-Na, which contains high levels of Na<sup>+</sup> and conveys superior anti-aging properties. Ulvan-Na restored intestinal barrier integrity in aged mice by reducing serum LPS leve","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-15T03:17:10.57Z","creation":"2026-05-15T03:11:56.378Z"},"accession":"S-EPMC12565729","cross_references":{"pubmed":["41149593"],"doi":["10.3390/md23100390"]}}