biostudies-literatureMora-Vargas CDSecretaría de Ciencia, Humanidades, Tecnología e Innovación2406https://www.ebi.ac.uk/biostudies/studies/S-EPMC12566430biostudies-literatureUnknown13(10)Adolescent pregnancy is a significant public health concern, with maternal and fetal risks compounded by pregnancy-related anatomical, hormonal, and urinary changes that predispose to urinary tract infections (UTIs). Alterations in the urinary microbiome may further influence infection susceptibility, yet little is known about its role during adolescent pregnancy. This study analyzed the urinary microbiome of adolescent pregnant patients and its association with UTI and recurrent UTI (rUTI) across gestation. Healthy adolescents were enrolled in the first trimester and followed through subsequent trimesters, with urine samples collected at each visit for microbiological diagnosis. Patients were classified as healthy (34 samples), single UTI (22 samples), or rUTI (31 samples), and oxford-nanMicroorganismsUrobiome Signatures of Recurrent Urinary Tract Infections in Adolescent Pregnancy: A Longitudinal Study.PMC12566430FOSISS FONDO SECTORIAL DE INVESTIGACIÓN EN SALUD Y SEGURIDAD SOCIAL 290038Mora-Vargas CDVillavicencio-Carrisoza OFlores-Rueda VAguilar-Ayala DAHelguera-Repetto ACRosas-Balan AGrobeisen-Duque OVillegas-Mota MICamargo-Marin LZaga-Clavellina VCastellanos-Diaz OLeon-Juarez MGuzman-Huerta MAguilera-Arreola MGMartinez-Salazar MGfalseUrobiome Signatures of Recurrent Urinary Tract Infections in Adolescent Pregnancy: A Longitudinal Study.Adolescent pregnancy is a significant public health concern, with maternal and fetal risks compounded by pregnancy-related anatomical, hormonal, and urinary changes that predispose to urinary tract infections (UTIs). Alterations in the urinary microbiome may further influence infection susceptibility, yet little is known about its role during adolescent pregnancy. This study analyzed the urinary microbiome of adolescent pregnant patients and its association with UTI and recurrent UTI (rUTI) across gestation. Healthy adolescents were enrolled in the first trimester and followed through subsequent trimesters, with urine samples collected at each visit for microbiological diagnosis. Patients were classified as healthy (34 samples), single UTI (22 samples), or rUTI (31 samples), and oxford-nan2025-01-01T00:00:00Z2025 Oct2026-05-14T03:12:06.68Z2026-05-14T03:08:44.473ZS-EPMC125664304115686410.3390/microorganisms13102406