{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hong L"],"funding":["the Science and Technology Development Fund, Macau SAR","the University of Macau","Zhuhai Science and Technology Plan Project in the Social Development Field"],"pagination":["1444"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12566646"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(10)"],"pubmed_abstract":["<b>Background/Objectives:</b> Allergic diseases (e.g., asthma, chronic urticaria) are increasing globally, but current anti-allergic drugs exhibit limitations in efficacy and safety. Traditional Chinese Medicine (TCM) emphasizes constitutional regulation for allergic diseases management. The allergic constitution prescription (ACP), a TCM formulation, lacks clear mechanistic insights. <b>Methods:</b> This study employs a novel network pharmacology approach integrating ultra-high performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS) to identify ACP's chemical components and compare its mechanisms with anti-allergic drugs. Chemical components of ACP were analyzed via UHPLC-Q-TOF-MS/MS, and allergic disease-related targets were collected from"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pubmed_title":["Characterization and Anti-Allergic Mechanisms of Bioactive Compounds in a Traditional Chinese Medicine Prescription Using UHPLC-Q-TOF-MS/MS, Network Pharmacology and Computational Simulations."],"pmcid":["PMC12566646"],"funding_grant_id":["0005/2024/AKP","2220004000117","MYRG-GRG2024-00150-ICMS-UMDF","CPG2025-00030-ICMS"],"pubmed_authors":["Hong L","Wang Q","Li S","Ip C","Qin Y","Zeng H","Xu W","Wang J","Zhao J","Duan X"],"additional_accession":[]},"is_claimable":false,"name":"Characterization and Anti-Allergic Mechanisms of Bioactive Compounds in a Traditional Chinese Medicine Prescription Using UHPLC-Q-TOF-MS/MS, Network Pharmacology and Computational Simulations.","description":"<b>Background/Objectives:</b> Allergic diseases (e.g., asthma, chronic urticaria) are increasing globally, but current anti-allergic drugs exhibit limitations in efficacy and safety. Traditional Chinese Medicine (TCM) emphasizes constitutional regulation for allergic diseases management. The allergic constitution prescription (ACP), a TCM formulation, lacks clear mechanistic insights. <b>Methods:</b> This study employs a novel network pharmacology approach integrating ultra-high performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS) to identify ACP's chemical components and compare its mechanisms with anti-allergic drugs. Chemical components of ACP were analyzed via UHPLC-Q-TOF-MS/MS, and allergic disease-related targets were collected from","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-14T03:20:53.813Z","creation":"2026-05-14T03:12:45.277Z"},"accession":"S-EPMC12566646","cross_references":{"pubmed":["41155559"],"doi":["10.3390/ph18101444"]}}