biostudies-literatureUnknown15(10)Liu YT<b>Objective:</b> The purpose of this study was to explore the impact of disability on dyadic quality of life (QoL) among stroke survivors and to examine the mediating role of social support in this process. <b>Methods:</b> Outcome measures were collected at four time points: baseline, 1 month, 3 months, and 6 months post-discharge. The Actor-Partner Interdependence Mediation Model was used to analyze the dyadic data. <b>Results:</b> A significant association was observed between a higher degree of disability and more severe depressive symptoms in stroke survivors (<i>β</i> = 0.626) and their spouses (<i>β</i> = 0.426). Survivors' disability had a negative impact on their own physical health (<i>β</i> = -3.731) and indirectly affected the physical health of the spouse caregiver through theNursing reports (Pavia, Italy)372https://www.ebi.ac.uk/biostudies/studies/S-EPMC12567538biostudies-literatureThe Interplay of Disability, Depression, Social Support, and Quality of Life in Middle-Aged and Young Couples Affected by Stroke: A Dyadic Path Analysis Using the Actor-Partner Interdependence Mediation Model.PMC12567538Ge SLi XChen SYZhang ZXXie JFLiu ZWMei YXWang SSZhang SXLiu YTXiang DDfalseThe Interplay of Disability, Depression, Social Support, and Quality of Life in Middle-Aged and Young Couples Affected by Stroke: A Dyadic Path Analysis Using the Actor-Partner Interdependence Mediation Model.<b>Objective:</b> The purpose of this study was to explore the impact of disability on dyadic quality of life (QoL) among stroke survivors and to examine the mediating role of social support in this process. <b>Methods:</b> Outcome measures were collected at four time points: baseline, 1 month, 3 months, and 6 months post-discharge. The Actor-Partner Interdependence Mediation Model was used to analyze the dyadic data. <b>Results:</b> A significant association was observed between a higher degree of disability and more severe depressive symptoms in stroke survivors (<i>β</i> = 0.626) and their spouses (<i>β</i> = 0.426). Survivors' disability had a negative impact on their own physical health (<i>β</i> = -3.731) and indirectly affected the physical health of the spouse caregiver through the2025-01-01T00:00:00Z2025 Oct2026-05-14T03:13:25.454Z2026-05-14T03:08:55.842ZS-EPMC125675384114968710.3390/nursrep15100372