{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shi X"],"funding":["Fandan Meng","China Postdoctoral Science Foundation","Foundation of the National Research Center of Engineering and Technology for Veterinary Biologicals","Heilongjiang Provincial Natural Science Foundation of China","Shibo Su"],"pagination":["1026"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12567548"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(10)"],"pubmed_abstract":["Pseudorabies virus (PRV), a major swine pathogen, causes severe neurological, respiratory, and reproductive disorders, resulting in substantial economic losses to the global swine industry. Previous studies have shown that the gD glycoprotein of PRV has an effective protective effect. In this study, we constructed a plasmid DNA vaccine (pVAX1-GD-Fc) encoding a gD protein fused with pig IgG Fc and evaluated the adjuvant effects of porcine cGAS, the universal STING complex mimic (UniSTING), or IFN-α in mice. The mice were immunized three times (days 0, 14, and 21) with pVAX1-GD-Fc in the presence or absence of an adjuvant, followed by lethal challenge with PRV-HLJ8 3 days after the final immunization. The results revealed that the pVAX1-GD-Fc group exhibited 20% mortality (1/5 mice) on day 7"],"journal":["Pathogens (Basel, Switzerland)"],"pubmed_title":["PRV gD-Based DNA Vaccine Candidates Adjuvanted with cGAS, UniSTING, or IFN-α Enhance Protective Immunity."],"pmcid":["PMC12567548"],"funding_grant_id":["GTKF(23)008","LH2023C023","2025M773034"],"pubmed_authors":["Meng F","Yang W","Su S","Yang Y","Qi X","Meng L","Xiang X","Wang H","Shi X","Tang Y","Cai X","An T"],"additional_accession":[]},"is_claimable":false,"name":"PRV gD-Based DNA Vaccine Candidates Adjuvanted with cGAS, UniSTING, or IFN-α Enhance Protective Immunity.","description":"Pseudorabies virus (PRV), a major swine pathogen, causes severe neurological, respiratory, and reproductive disorders, resulting in substantial economic losses to the global swine industry. Previous studies have shown that the gD glycoprotein of PRV has an effective protective effect. In this study, we constructed a plasmid DNA vaccine (pVAX1-GD-Fc) encoding a gD protein fused with pig IgG Fc and evaluated the adjuvant effects of porcine cGAS, the universal STING complex mimic (UniSTING), or IFN-α in mice. The mice were immunized three times (days 0, 14, and 21) with pVAX1-GD-Fc in the presence or absence of an adjuvant, followed by lethal challenge with PRV-HLJ8 3 days after the final immunization. The results revealed that the pVAX1-GD-Fc group exhibited 20% mortality (1/5 mice) on day 7","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-11T03:12:38.12Z","creation":"2026-06-11T03:08:12.364Z"},"accession":"S-EPMC12567548","cross_references":{"pubmed":["41156640"],"doi":["10.3390/pathogens14101026"]}}