{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Huang H"],"pubmed_abstract":["This study comprehensively investigated the metabolic profiling, pharmacological potential, and biosynthetic regulation of alkaloids in three <i>Murraya</i> species (<i>M. exotica</i>, <i>M. kwangsiensis</i>, and <i>M. tetramera</i>). Through integrative multi-omics approaches, including metabolomics, transcriptomics, network pharmacology, and molecular docking, a total of 77 alkaloids were identified, categorized into 18 structural classes. Comparative analysis revealed species-specific accumulation patterns, with 50 alkaloids shared among all three species and unique metabolites detected in <i>M. exotica</i> and <i>M. kwangsiensis</i>. Principal component analysis (PCA) confirmed distinct alkaloid profiles, highlighting interspecies divergence. Network pharmacology identified 427 potenti"],"journal":["Frontiers in plant science"],"pagination":["1675533"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12568637"],"repository":["biostudies-literature"],"pubmed_title":["Metabolic profiling and pharmacological evaluation of alkaloids in three &lt;i&gt;Murraya&lt;/i&gt; species."],"pmcid":["PMC12568637"],"pubmed_authors":["Peng Y","Geng X","Huang H","Tang C","Liu Q","Wang X","Chen R","Liu F","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Metabolic profiling and pharmacological evaluation of alkaloids in three &lt;i&gt;Murraya&lt;/i&gt; species.","description":"This study comprehensively investigated the metabolic profiling, pharmacological potential, and biosynthetic regulation of alkaloids in three <i>Murraya</i> species (<i>M. exotica</i>, <i>M. kwangsiensis</i>, and <i>M. tetramera</i>). Through integrative multi-omics approaches, including metabolomics, transcriptomics, network pharmacology, and molecular docking, a total of 77 alkaloids were identified, categorized into 18 structural classes. Comparative analysis revealed species-specific accumulation patterns, with 50 alkaloids shared among all three species and unique metabolites detected in <i>M. exotica</i> and <i>M. kwangsiensis</i>. Principal component analysis (PCA) confirmed distinct alkaloid profiles, highlighting interspecies divergence. Network pharmacology identified 427 potenti","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-14T03:17:39.11Z","creation":"2026-05-14T03:12:06.209Z"},"accession":"S-EPMC12568637","cross_references":{"pubmed":["41169715"],"doi":["10.3389/fpls.2025.1675533"]}}