{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lenglart L"],"funding":["Centro de Investigación Biotecnológica en Red de Enfermedades Infecciosas","ZonMw","Netherlands Organisation for Health Research and Development","European Society for Paediatric Infectious Diseases","Leids Universitair Medisch Centrum","Instituto de Investigación Sanitaria Gregorio Marañón","Fondazione IRCCS Policlinico San Matteo","Karolinska Institutet","National and Kapodistrian University of Athens","CY Cergy Paris Université","Newcastle University","Universidade de Lisboa","Medizinische Universität Graz","School of Medicine, Duke University","Univerza v Ljubljani","Landspítali Háskólasjúkrahús","Erasmus Medisch Centrum"],"pagination":["101497"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12569802"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["59"],"pubmed_abstract":["<h4>Background</h4>After lifting non-pharmaceutical interventions (NPIs) against the transmission of SARS-CoV-2, various countries experienced an increase in invasive Group A Streptococcal (iGAS) infections. We aimed to characterise the paediatric outbreak across Europe and to analyse the influence of viral infections.<h4>Methods</h4>We conducted an interrupted time-series analysis based on data from 15 European countries from the PEGASUS consortium. We assessed the evolution of the number of iGAS cases aged 1 month to 18 years between 01/01/2018 and 03/31/2024, comparing the post-NPIs period (01-04-2022 until 31-03-2024) to the baseline period (01-01-2018 until 31-03-2020). Further analyses were performed by country, clinical phenotype, age and severity, including sensitivity analyses. We"],"journal":["The Lancet regional health. Europe"],"pubmed_title":["Paediatric invasive group A streptococcal infections and associations with viral infections in 15 European countries after lifting non-pharmaceutical interventions against SARS-CoV-2: an interrupted time-series analysis."],"pmcid":["PMC12569802"],"funding_grant_id":["10430072110007","27100","28041","LV1004","171 65"],"pubmed_authors":["Van Veen M","Blazquez-Gamero D","Kolnik M","Buddingh EP","Ludwikowska K","Plankar Srovin T","Zaman M","Tulling A","Aguilera-Alonso D","Shan A","Tatsi EB","Ezinwoke C","Nygaard U","Friaes A","Kahlert CR","Michos A","Velimirovic I","Tsilifis C","Giske C","Daina M","Dourdouna MM","Hol J","Syngelou A","Castagnoli R","McGalliard R","Strenger V","Carrol E","Ramirez M","Von Both U","Pokorn M","Saavedra-Lozano J","Rhedin S","Calvo C","Hawkins R","Holm M","Ozmen I","Raghoenath P","Nagle A","PEGASUS Consortium","van Kempen E","Zavadska D","McArdle A","Thors VS","Hertting O","Seme K","Syrimi N","Rozemeijer W","Vas DG","Marseglia GL","Ouldali N","Boeddha NP","Tsolia M","Oostenbrink R","Tokarczyk M","Tilmanne A","Gouveia C","Borensztajn D","Till H","Wilfing S","Dekkers F","Vincek K","Buonsenso D","Kohlmaier B","Emonts M","Roisin S","Nijman RG","Lewis-Burke N","Niederer-Loher A","Lenglart L"],"additional_accession":[]},"is_claimable":false,"name":"Paediatric invasive group A streptococcal infections and associations with viral infections in 15 European countries after lifting non-pharmaceutical interventions against SARS-CoV-2: an interrupted time-series analysis.","description":"<h4>Background</h4>After lifting non-pharmaceutical interventions (NPIs) against the transmission of SARS-CoV-2, various countries experienced an increase in invasive Group A Streptococcal (iGAS) infections. We aimed to characterise the paediatric outbreak across Europe and to analyse the influence of viral infections.<h4>Methods</h4>We conducted an interrupted time-series analysis based on data from 15 European countries from the PEGASUS consortium. We assessed the evolution of the number of iGAS cases aged 1 month to 18 years between 01/01/2018 and 03/31/2024, comparing the post-NPIs period (01-04-2022 until 31-03-2024) to the baseline period (01-01-2018 until 31-03-2020). Further analyses were performed by country, clinical phenotype, age and severity, including sensitivity analyses. We","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-10T05:20:06.188Z","creation":"2026-06-10T03:07:14.83Z"},"accession":"S-EPMC12569802","cross_references":{"pubmed":["41170145"],"doi":["10.1016/j.lanepe.2025.101497"]}}