biostudies-literatureLenglart LCentro de Investigación Biotecnológica en Red de Enfermedades InfecciosasZonMwNetherlands Organisation for Health Research and DevelopmentEuropean Society for Paediatric Infectious DiseasesLeids Universitair Medisch CentrumInstituto de Investigación Sanitaria Gregorio MarañónFondazione IRCCS Policlinico San MatteoKarolinska InstitutetNational and Kapodistrian University of AthensCY Cergy Paris UniversitéNewcastle UniversityUniversidade de LisboaMedizinische Universität GrazSchool of Medicine, Duke UniversityUniverza v LjubljaniLandspítali HáskólasjúkrahúsErasmus Medisch Centrum101497https://www.ebi.ac.uk/biostudies/studies/S-EPMC12569802biostudies-literatureUnknown59<h4>Background</h4>After lifting non-pharmaceutical interventions (NPIs) against the transmission of SARS-CoV-2, various countries experienced an increase in invasive Group A Streptococcal (iGAS) infections. We aimed to characterise the paediatric outbreak across Europe and to analyse the influence of viral infections.<h4>Methods</h4>We conducted an interrupted time-series analysis based on data from 15 European countries from the PEGASUS consortium. We assessed the evolution of the number of iGAS cases aged 1 month to 18 years between 01/01/2018 and 03/31/2024, comparing the post-NPIs period (01-04-2022 until 31-03-2024) to the baseline period (01-01-2018 until 31-03-2020). Further analyses were performed by country, clinical phenotype, age and severity, including sensitivity analyses. WeThe Lancet regional health. EuropePaediatric invasive group A streptococcal infections and associations with viral infections in 15 European countries after lifting non-pharmaceutical interventions against SARS-CoV-2: an interrupted time-series analysis.PMC12569802104300721100072710028041LV1004171 65Van Veen MBlazquez-Gamero DKolnik MBuddingh EPLudwikowska KPlankar Srovin TZaman MTulling AAguilera-Alonso DShan ATatsi EBEzinwoke CNygaard UFriaes AKahlert CRMichos AVelimirovic ITsilifis CGiske CDaina MDourdouna MMHol JSyngelou ACastagnoli RMcGalliard RStrenger VCarrol ERamirez MVon Both UPokorn MSaavedra-Lozano JRhedin SCalvo CHawkins RHolm MOzmen IRaghoenath PNagle APEGASUS Consortiumvan Kempen EZavadska DMcArdle AThors VSHertting OSeme KSyrimi NRozemeijer WVas DGMarseglia GLOuldali NBoeddha NPTsolia MOostenbrink RTokarczyk MTilmanne AGouveia CBorensztajn DTill HWilfing SDekkers FVincek KBuonsenso DKohlmaier BEmonts MRoisin SNijman RGLewis-Burke NNiederer-Loher ALenglart LfalsePaediatric invasive group A streptococcal infections and associations with viral infections in 15 European countries after lifting non-pharmaceutical interventions against SARS-CoV-2: an interrupted time-series analysis.<h4>Background</h4>After lifting non-pharmaceutical interventions (NPIs) against the transmission of SARS-CoV-2, various countries experienced an increase in invasive Group A Streptococcal (iGAS) infections. We aimed to characterise the paediatric outbreak across Europe and to analyse the influence of viral infections.<h4>Methods</h4>We conducted an interrupted time-series analysis based on data from 15 European countries from the PEGASUS consortium. We assessed the evolution of the number of iGAS cases aged 1 month to 18 years between 01/01/2018 and 03/31/2024, comparing the post-NPIs period (01-04-2022 until 31-03-2024) to the baseline period (01-01-2018 until 31-03-2020). Further analyses were performed by country, clinical phenotype, age and severity, including sensitivity analyses. We2025-01-01T00:00:00Z2025 Dec2026-06-10T05:20:06.188Z2026-06-10T03:07:14.83ZS-EPMC125698024117014510.1016/j.lanepe.2025.101497